Author

P. Balfe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

J. A. McKeating· 4 shared X. Zhuang· 4 shared J. M. Harris· 3 shared H. Borrmann· 2 shared M. Schilling· 2 shared P. A. Wing· 2 shared P. Borrow· 2 shared A. Claydon· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersMicrobiology

J. A. McKeating

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4 papers

Recent·Most cited

Circadian regulation of human immunodeficiency virus type 1 replication

H. Borrmann, G. Ulkar, A. E. Kliszczak, D. Ismed, M. Schilling, A. Magri, J. M. Harris, P. Balfe, S. Vasudevan, P. Borrow, X. Zhuang, J. A. McKeating

This study shows HIV-1 replication is regulated by circadian rhythms through interactions between transcription factors BMAL1, REV-ERB, and ROR, with implications for HIV therapy.

bioRxiv · Nov 30, 2022 · PreprintMicrobiology

Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model.

P. A. Wing, M. Prange-Barczynska, A. Cross, S. Crotta, C. Orbegozo Rubio, X. Cheng, J. M. Harris, X. Zhuang, R. L. Johnson, K. A. Ryan, Y. Hall, M. W. Carroll, F. Issa, P. Balfe, A. Wack, , J. A. McKeating

This study shows that activating HIF signaling reduces SARS-CoV-2 infection and respiratory symptoms in hamsters by decreasing viral RNA and epithelial damage.

bioRxiv · Mar 15, 2022Microbiology

The CCCTC-binding factor CTCF represses hepatitis B virus Enhancer I and regulates viral transcription

V. D'Arienzo, J. Ferguson, G. Giraud, F. Chapus, J. M. Harris, P. A. Wing, A. Claydon, S. Begum, X. Zhuang, P. Balfe, B. Testoni, J. A. McKeating, J. L. Parish

This study identifies CTCF as a repressor of HBV transcription by binding to Enhancer I and reducing pre-genomic RNA levels.

Cellular Microbiology · Oct 16, 2020Peer-reviewedMicrobiology

Pharmacological activation of the circadian component REV-ERB inhibits HIV-1 replication

H. Borrmann, R. Davies, M. Dickinson, I. Pedroza-Pacheco, M. Schilling, A. Vaughan-Jackson, W. James, P. Balfe, P. Borrow, J. A. McKeating, X. Zhuang

This study shows that REV-ERB agonists inhibit HIV-1 replication by suppressing its promoter activity in multiple cell types.

Scientific Reports · Aug 6, 2020Peer-reviewedMicrobiology