W. James

Hypoxia dampens innate immune signalling at early time points and increases Zika virus replication in iPSC-derived macrophages

This study shows that hypoxia reduces interferon-stimulated gene expression and increases Zika virus replication in iPSC-derived macrophages.

The Western Lake Erie Culture Collection: A promising resource for evaluating the physiological and genetic diversity of Microcystis and its associated microbiome

The paper isolates and sequences 21 Microcystis cultures from Lake Erie, revealing genomic diversity and toxin production variability, along with associated bacterial communities.

Resistance bioassays and allele characterisation inform analysis of Spodoptera frugiperda (Lepidoptera: Noctuidae) introduction pathways in Asia and Australia

The paper uses bioassays and allele characterization to analyze the introduction pathways of Spodoptera frugiperda in Asia and Australia, finding multiple introductions and resistance patterns.

Absolute quantitation of individual SARS-CoV-2 RNA molecules: a new paradigm for infection dynamics and variant differences

The paper quantifies SARS-CoV-2 RNA molecules using smFISH, revealing genomic RNA stability, cell-to-cell replication variability, and slower replication kinetics for the B.1.1.7 variant compared to the Victoria strain.

Potent SARS-CoV-2 neutralizing antibodies selected from a human antibody library constructed decades ago

The paper identifies potent SARS-CoV-2 neutralizing antibodies from a pre-pandemic human antibody library, showing high somatic hypermutation and specific binding to the spike protein.

SARS-CoV-2 Assembly and Egress Pathway Revealed by Correlative Multi-modal Multi-scale Cryo-imaging

This study uses cryo-imaging to reveal SARS-CoV-2 replication, assembly, and egress pathways in infected cells.

Pharmacological activation of the circadian component REV-ERB inhibits HIV-1 replication

This study shows that REV-ERB agonists inhibit HIV-1 replication by suppressing its promoter activity in multiple cell types.