S. Islam

Loss of FBXO31-mediated γH2AX foci formation impairs initiation of NHEJ and HR repair pathways, and sensitizes breast cancer to therapy

This study shows that FBXO31-mediated γH2AX foci formation is essential for DNA repair pathways and that its loss sensitizes breast cancer to chemotherapy.

Visualizing Mitochondrial Heme Flow through GAPDH to Targets in Living Cells and its Regulation by NO

The paper visualizes mitochondrial heme flow through GAPDH to IDO1 in living cells and shows NO regulates heme reallocation between GAPDH and IDO1 based on NO levels.

Epicardial reservoir-enabled multidose delivery of exogenous FSTL1 leads to improved cardiac function, healing, and angiogenesis.

This study investigates the effects of multidose FSTL1 delivery via an epicardial reservoir in a rat MI model, finding improved cardiac function, healing, and angiogenesis with increasing doses.

Anellovirus Structure Reveals a Mechanism for Immune Evasion

This paper determines the structure of an anellovirus, revealing how its unique surface features enable immune evasion by hiding conserved epitopes and exposing diverse ones as decoys.

Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma

This study shows that extracellular adenosine promotes an immunosuppressive microenvironment in PDAC by enhancing myeloid cell infiltration and resistance to immunotherapy, and that blocking adenosine pathway components improves therapeutic outcomes.

Human iPSC-Vascular Smooth Muscle Cell Spheroids Demonstrate Size-dependent Alterations in Cellular Viability and Secretory Function

This study investigates how the size of hiPSC-VSMC spheroids affects cell viability and paracrine secretion, finding that 10,000 cells optimizes both.

Exploring different virulent proteins of human respiratory syncytial virus for designing a novel epitope-based polyvalent vaccine: Immunoinformatics and molecular dynamics approaches

This study uses immunoinformatics and molecular dynamics to design a polyvalent epitope-based vaccine against RSV-A and RSV-B, selecting conserved epitopes and validating structural stability.

A widely-distributed HIV-1 provirus elimination assay to evaluate latency-reversing agents in vitro

The paper develops a new assay to evaluate latency-reversing agents by eliminating HIV-1 proviruses in a long-term cell culture system.

Neurotoxic Amyloidogenic Peptides Identified in the Proteome of SARS-COV2: Potential Implications for Neurological Symptoms in COVID-19

The paper identifies amyloidogenic peptides in SARS-CoV-2 that are toxic to neuronal cells, suggesting they may contribute to neurological symptoms and long COVID.

A human antibody that broadly neutralizes betacoronaviruses protects against SARS-CoV-2 by blocking the fusion machinery

This paper identifies a human antibody that broadly neutralizes betacoronaviruses by targeting the stem helix, showing protection against SARS-CoV-2 and potential for vaccine design.

Increased wheat protein content via introgression of a HMW glutenin selectively reshapes the grain proteome

Introgression of the 1Ay21* HMW-GS increases wheat grain protein content and improves bread-making quality by reshaping the grain proteome network.

Effect of sanitation improvements on soil-transmitted helminth eggs in courtyard soil from rural Bangladesh: Evidence from a cluster-randomized controlled trial

This study evaluates a sanitation program's effect on reducing soil-transmitted helminth eggs in courtyard soil, finding no significant impact despite high latrine uptake.

In-vivo evaluation of the anti-diarrheal effect of Lactococcus lactis subspecies lactis and Lactococcus piscium isolated from yogurt.

This study isolates and evaluates Lactococcus lactis subspecies lactis and Lactococcus piscium from yogurt for their anti-diarrheal effects against castor oil-induced diarrhea in rats.

Impaired expression of chloroplast HSP90C chaperone activates plant defense responses leading to a disease symptom-like phenotype

The paper shows that silencing chloroplast HSP90C in tobacco causes chlorosis via downregulation of photosynthesis genes and activation of immune responses including cell death.