Author

P.-C. Chen

National Taiwan University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Biophysics· 1 Cancer Biology· 1 Genetic & Genomic Medicine· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:electrophysiology· 1

Frequent Co-Authors

A. Baker· 1 shared A. Dunn· 1 shared A. Graham· 1 shared A. Singh· 1 shared C.-Y. Huang· 1 shared E. Takematsu· 1 shared H.-S. Huang· 1 shared Hurng‐Yi WangiD· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperBioengineering

A. Baker

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Author profile →

6 papers

Recent·Most cited

Comprehensive Analysis of Mitochondrial DNA Variation in the Taiwan Biobank: Implications for Complex Traits and Population Genetics

Ting-Hsuan Chou, Pei-Miao Chien, P.-C. Chen, Ni‐Chung Lee, Hurng‐Yi Wang, Yi‐Cheng Chang, Pei‐Lung Chen, Jacob Shujui Hsu

This study analyzes mitochondrial DNA variation in the Taiwan Biobank, identifying pathogenic variants and associations with complex traits like myopia and renal function.

medRxiv · Oct 28, 2024 · PreprintGenetic & Genomic Medicine

Ovulation sources coagulation protease cascade and hepatocyte growth factor to support physiological growth and malignant transformation

H.-S. Huang, P.-C. Chen, S.-C. Chu, M.-H. Lee, C.-Y. Huang, T.-Y. Chu

This paper identifies the coagulation protease cascade and hepatocyte growth factor (HGF) as mediators of sustained transformation activity from ovulation, promoting both physiological repair and malignant transformation of ovarian tissues.

bioRxiv · Jun 16, 2021Cancer Biology

Age-related losses in cardiac autonomic activity during a daytime nap

P.-C. Chen, N. Sattari, L. N. Whitehurst, S. C. Mednick

This study compares parasympathetic activity during daytime naps and wakefulness in young and older adults, finding reduced vagal modulation during NREM sleep in older adults but not during wakefulness.

bioRxiv · Jun 26, 2020Physiology

Transmembrane Stem Cell Factor Protein Therapeutics EnhanceRevascularization in Ischemia without Mast Cell Activation

E. Takematsu, J. Auster, P.-C. Chen, S. Srinath, S. Canga, A. Singh, M. Majid, M. Sherman, A. Dunn, A. Graham, P. Martin, A. Baker

This study develops tmSCF-based therapeutics that enhance revascularization in ischemia without activating mast cells, using proteoliposomes and lipid nanodiscs as delivery systems.

bioRxiv · Apr 6, 2020Bioengineering

Integrative model to coordinate the oligomerization and aggregation mechanisms of CCL5

Y.-C. Chen, S.-P. Chen, J.-Y. Li, P.-C. Chen, Y.-Z. Lee, K.-M. Li, R. Zarivach, Y.-J. Sun, S.-C. Sue

This study identifies two dimer-dimer interactions and one aggregation mechanism in CCL5 oligomerization using NMR and biophysical analyses.

bioRxiv · Sep 3, 2019Biochemistry

Structure-based screening of binding affinities via small-angle X-ray scattering

P.-c. Chen, P. Masiewicz, K. Perez, J. Hennig

This paper demonstrates a method using SAXS to quantify ligand binding affinities without prior structural knowledge, showing its potential for drug discovery.

bioRxiv · Jul 31, 2019Biophysics