Author
Wellcome Sanger Institute
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
Sho Iwama, Daniel P. Gitterman, Timothy Brendler-Spaeth, Andrew J. Waters, Holly Robertson, Magdalena E Strauß, D. Adams, Sarah E Cooper, Qianxin Wu, Andrew Roger Bassett
SELECT-seq enables rapid, scalable SNP-specific enrichment of single cells for genotype-phenotype analysis without cloning.
bioRxiv · Jul 8, 2026 · PreprintMolecular Biology
Magdalena E Strauß, Andrew J. Waters, Holly Roberston, Timothy Brendler-Spaeth, Aleksander M. Gontarczyk, Prashant Gupta, Shikha Kataria, Daniel P. Gitterman, Tumisang Ntereke, Leah Wells, Jamie Billington, Andrew Roger Bassett, Sarah Cooper, D. Adams
Saturation-seq combines genome editing and single-cell RNA-seq to quantify variant effects on NFE2L2, accurately distinguishing pathogenic from benign variants.
bioRxiv · Jul 4, 2026 · PreprintGenomics
E. A. Moran, K. Salas-Briceno, A. Aguilera, T. Keane, D. Adams, J. Lilue, S. R. Ross
The paper identifies IFI207 as a rapidly evolving antiviral factor that stabilizes STING, enhancing the host's response to viral infections.
bioRxiv · Jan 19, 2023 · PreprintMicrobiology
S. Matsuyama, M. Matsuyama, J. Ortega, Y. Fedorov, J. Scott-McKean, J. Muller-Greven, M. Buck, D. Adams, B. Jastrzebska, W. Greenlee
The paper identifies and develops M109S, a small molecule that inhibits mitochondria-dependent apoptosis in various cell types and models.
bioRxiv · Oct 12, 2022 · PreprintCell Biology
L. Valcarcel-Jimenez, C. Rogerson, C. Yong, C. Schmidt, M. Yang, V. Harle, V. Offord, K. Wong, A. N. Mora, A. Speed, V. Caraffini, M. G. B. Tran, E. R. Maher, G. D. Stewart, S. Vanharanta, , C. Frezza
This study identifies HIRA depletion as a factor that enhances proliferation and invasion of Fh1-deficient cells, revealing a mechanism involving MYC activation and nucleotide metabolism.
bioRxiv · Jun 4, 2022Cancer Biology
A. Vaishnavi, J. Juan, M. T. Scherzer, J. E. VanVeen, C. Stehn, C. S. Hackett, A. Dupuy, S. A. Chmura, L. van der Weyden, J. Y. Newberg, K. M. Mann, A. Liu, A. G. Rust, W. A. Weiss, D. Adams, , M. McMahon
This paper identifies RBMS3 as a tumor suppressor that cooperates with BRAFV600E to promote malignant lung cancer progression using transposon mutagenesis and CRISPR validation.
bioRxiv · Feb 28, 2022 · PreprintCancer Biology
P. Jaako, A. Faille, S. Tan, C. C. Wong, N. Escudero-Urquijo, P. Castro-Hartmann, P. Wright, C. Hilcenko, D. Adams, A. Warren
This study shows eIF6 dynamically couples ribosome maturation and translation by sequestering 60S subunits, and its disruption impairs erythropoiesis in mice.
bioRxiv · Sep 6, 2021Cell Biology
N. R. Campbell, A. Rao, X. Zhang, M. Baron, S. Heilmann, M. Deforet, C. Kenny, L. Ferretti, T.-H. Huang, M. Garg, J. Nsengimana, E. Montal, M. Tagore, M. Hunter, J. Newton-Bishop, , R. White
This study shows that melanoma metastasis is promoted by heterotypic clusters formed between proliferative and invasive cell states, mediated by TFAP2.
bioRxiv · Aug 24, 2020 · PreprintCancer Biology
V. Iyer, K. Boroviak, M. Thomas, B. Doe, E. Ryder, D. Adams
The paper assesses CRISPR-Cas9 off-target effects in gene-edited mice using trio sequencing and finds no unexpected off-target activity.
bioRxiv · Feb 9, 2018Bioengineering