Author

R. C. Kretsch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:structural biology· 2 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

R. Das· 2 shared A. J. Simpkin· 1 shared A. Manglik· 1 shared A. S. Powers· 1 shared C. Azumaya· 1 shared C. Billesboelle· 1 shared D. J. Rigden· 1 shared E. Westhof· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiophysics

R. Das

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Author profile →

3 papers

Recent·Most cited

Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses

R. C. Kretsch, L. Xu, I. N. Zheludev, X. Zhou, R. Huang, G. Nye, S. Li, K. Zhang, W. Chiu, R. Das

This paper determines the 3D structures of SL5 RNA domains from six coronaviruses, revealing conserved tertiary features with implications for protein-binding and antiviral targets.

Proceedings of the National Academy of Sciences · Mar 1, 2024Peer-reviewedBiophysics

Assessment of three-dimensional RNA structure prediction in CASP15

R. Das, R. C. Kretsch, A. J. Simpkin, T. Mulvaney, P. Pham, R. Rangan, F. Bu, R. M. Keegan, M. Topf, D. J. Rigden, Z. Miao, E. Westhof

This paper evaluates RNA 3D structure prediction methods in CASP15, finding that non-deep learning groups outperformed deep learning models, with challenges in fine details and model ranking.

bioRxiv · Apr 25, 2023Biophysics

Structure of human ferroportin bound to hepcidin reveals mechanisms of iron homeostasis

C. Billesboelle, C. Azumaya, R. C. Kretsch, A. S. Powers, S. Gonen, S. Schneider, T. Arvedson, R. Dror, Y. Cheng, A. Manglik

This study determines the cryo-EM structures of human ferroportin bound to hepcidin and identifies mechanisms of iron homeostasis regulation.

bioRxiv · Mar 16, 2020 · PreprintBiochemistry