Author

R. Devarajan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Ahtikoski· 2 shared A. Manninen· 2 shared G.-H. Wei· 2 shared M. H. Vaarala· 2 shared Q. Zhang· 2 shared T. Wenta· 2 shared A. Schmidt· 1 shared B. Luo· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersCancer Biology

A. Ahtikoski

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Author profile →

3 papers

Recent·Most cited

TEAD1 regulates ITGA1 and ITGA2 to control prostate cancer progression

S. P. Cruz, Q. Zhang, R. Devarajan, C. Paia, B. Luo, K. Zhang, J. Xia, A. Ahtikoski, M. H. Vaarala, T. Wenta, G.-H. Wei, A. Manninen

This study identifies TEAD1 as a regulator of ITGA1 and ITGA2 in prostate cancer, showing their loss promotes tumor progression via TGFβ1-driven EMT.

bioRxiv · Apr 12, 2023Cancer Biology

Collagen XVIII promotes breast cancer through EGFR/ErbB signaling and its ablation improves the efficacy of ErbB-targeting inhibitors

R. Devarajan, H. Peltoketo, V. Izzi, H. J. Ruotsalainen, S. Kauppila, M.-R. Vaisanen, G. Rask, G. Martinez-Nieto, S.-M. Karppinen, T. Vaisanen, I. Kaur, J. P. Koivunen, T. Sasaki, R. Winqvist, F. Warnberg, , R. Heljasvaara

This study shows that collagen XVIII promotes breast cancer via EGFR/ErbB signaling and sustains cancer stem cells, and its inhibition enhances the effectiveness of ErbB-targeting therapies.

bioRxiv · Jan 10, 2022 · PreprintCancer Biology

Disassembly of hemidesmosomes promotes tumorigenesis in PTEN-negative prostate cancer by targeting plectin into focal adhesions

T. Wenta, A. Schmidt, Q. Zhang, R. Devarajan, P. Singh, X. Yang, A. Ahtikoski, M. H. Vaarala, G.-H. Wei, A. Manninen

This study shows that loss of PTEN and hemidesmosomes in prostate cancer promotes tumorigenesis by activating EGFR/PI3K/Akt and FAK/Src pathways through plectin mislocalization.

bioRxiv · Nov 8, 2021Cancer Biology