Author

R. Dries

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Organism:human· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:deep learning· 2 Assay:scRNA-seq· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

B. Sharma· 3 shared R. E. George· 3 shared H. Huang· 2 shared M. Krajewska· 2 shared A. B. Balazs· 1 shared A. C. Belkina· 1 shared A. C. Gross· 1 shared A. Crespo· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersCancer Biology

B. Sharma

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The MYCN 5' UTR as a therapeutic target in neuroblastoma

M. P. Volegova, L. E. Brown, U. Banerjee, R. Dries, B. Sharma, A. Kennedy, J. A. Porco, R. E. George

This study investigates the therapeutic potential of targeting eIF4A1 to inhibit MYCN expression in neuroblastoma by exploiting its role in translation of polypurine-rich 5' UTRs.

bioRxiv · Feb 20, 2024Cancer Biology

Aberrant activation of wound healing programs within the metastatic niche facilitates lung colonization by osteosarcoma cells

J. B. Reinecke, L. Jimenez Garcia, A. C. Gross, M. Cam, M. V. Cannon, M. J. Gust, J. P. Sheridan, B. E. Gryder, R. Dries, R. D. Roberts

This study identifies fibrosis as a targetable vulnerability in osteosarcoma lung metastasis by showing nintedanib inhibits metastatic progression through anti-fibrotic effects.

bioRxiv · Jan 10, 2024Cancer Biology

Cell lineage as a predictor of immune response in neuroblastoma

S. Sengupta, S. Das, A. Crespo, B. Miller, B. Sharma, S. Zhang, R. Dries, H. Huang, M. Krajewska, D. N. Debruyne, L. Soriano, M. A. Cohen, R. Versteeg, R. Jaenisch, S. Spranger, , R. E. George

This study identifies cell lineage as a key determinant of immune response in neuroblastoma by analyzing transcriptional signatures from 498 tumors and showing that mesenchymal-like cells are more immunogenic than adrenergic neuron-like cells.

bioRxiv · Jan 29, 2021Cancer Biology

Multi-Modal Profiling of Human Fetal Liver-Derived Hematopoietic Stem Cells Reveals the Molecular Signature of Engraftment Potential

K. Vanuytsel, C. Villacorta-Martin, J. Lindstrom-Vautrin, Z. Wang, W. F. Garcia-Beltran, V. Vrbanac, T. M. Matte, T. W. Dowrey, S. S. Kumar, M. Li, R. Dries, J. D. Campbell, A. C. Belkina, A. B. Balazs, G. J. Murphy

The paper profiles human fetal liver hematopoietic stem cells using multi-modal data to identify a molecular signature associated with engraftment potential.

bioRxiv · Nov 11, 2020Cell Biology

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

M. Krajewska, R. Dries, A. V. Grassetti, S. Dust, Y. Gao, H. Huang, B. Sharma, D. S. Day, N. Kwiatkowski, M. Pomaville, O. Dodd, E. Chipumuro, T. Zhang, A. L. Greenleaf, G.-C. Yuan, , R. E. George

This study shows CDK12 inhibition causes premature cleavage and polyadenylation in long DNA damage response genes, linked to their length and polyadenylation site distribution.

bioRxiv · Nov 30, 2018Cancer Biology