IRF8 Governs Tumor-Associated Macrophage Control of T Cell Exhaustion
B. Nixon, F. Kuo, M. Liu, K. Capistrano, M. Do, R. Franklin, X. Wu, E. Kansler, R. Srivastava, T. Purohit, A. Sanchez, L. Vuong, C. Krishna, H. Morse, J. Hsieh, , M. Li
This study identifies IRF8 as a key factor in tumor-associated macrophages (TAMs) that induce T cell exhaustion by presenting cancer antigens, and shows its association with poor patient survival in renal cell carcinoma.
bioRxiv · Mar 12, 2020 · PreprintImmunology