Author

T. Kurth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biophysics· 3 Bioengineering· 1 Evolutionary Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 5 Organism:mouse· 5 Assay:imaging· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:metabolomics· 2 Research Focus:spatial domain detection· 2

Frequent Co-Authors

M. Solimena· 4 shared A. V. Taubenberger· 3 shared J. Guck· 3 shared A. Müller· 2 shared C. S. Xu· 2 shared D. Schmidt· 2 shared H. F. Hess· 2 shared J. Broichhagen· 2 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersCell Biology

M. Solimena

Mutual co-authors in cluster

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10 papers

Recent·Most cited

Structure, interaction, and nervous connectivity of beta cell primary cilia

A. Müller, N. Klena, S. Pang, L. E. G. Garcia, O. Topcheva, S. Aurrecoechea Duran, D. Sulaymankhil, M. Seliskar, H. Mziaut, E. Schöniger, D. Friedland, N. Kipke, S. Kretschmar, C. Münster, J. Weitz, , M. Solimena

This study reveals the structural and spatial organization of beta cell primary cilia in mouse and human islets, showing their interactions with neighboring cells and nerves, and their role in islet connectivity.

bioRxiv · Dec 1, 2023Cell Biology

Metabolic responses of normal rat kidneys to a high salt intake.

S. Shimada, B. R. Hoffmann, C. Yang, T. Kurth, A. S. Greene, M. Liang, R. K. Dash, A. W. Cowley

This study examines how normal rat kidneys respond metabolically to a high salt diet, showing increased glycolysis and oxygen consumption despite reduced TCA cycle enzyme expression.

bioRxiv · Jan 18, 2023Physiology

Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs

E. Kemter, A. Müller, M. Neukam, A. Ivanova, N. Klymiuk, S. Renner, K. Yang, J. Broichhagen, M. Kurome, V. Zakhartchenko, B. Kessler, K.-P. Knoch, M. Bickle, B. Ludwig, K. Johnsson, , M. Solimena

This study develops a transgenic pig model with SNAP-tagged insulin to investigate in vivo insulin secretory granule dynamics and turnover.

bioRxiv · Apr 23, 2021Cell Biology

AI-Driven Multiscale Simulations Illuminate Mechanisms of SARS-CoV-2 Spike Dynamics

L. Casalino, A. C. Dommer, Z. Gaieb, E. P. Barros, T. Sztain, S.-H. Ahn, A. Trifan, A. Brace, H. Ma, H. Lee, M. Turilli, A. Bogetti, S. Khalid, L. Chong, C. Simmerling, , R. E. Amaro

This paper develops an AI-driven workflow to simulate SARS-CoV-2 spike protein dynamics, revealing glycan shield structure, spike glycans' role in infectivity, and spike-ACE2 interactions.

bioRxiv · Nov 19, 2020Biophysics

3D FIB-SEM reconstruction of microtubule-organelle interaction in whole primary mouse beta cells

A. Mueller, D. Schmidt, C. S. Xu, S. Pang, J. V. D'Costa, S. Kretschmar, C. Muenster, T. Kurth, F. Jug, M. Weigert, H. F. Hess, M. Solimena

The paper provides 3D reconstructions of microtubule networks in primary mouse beta cells and shows their role in insulin secretory granule positioning.

bioRxiv · Oct 7, 2020Cell Biology

Purification of age-distinct insulin secretory granules through antigen restriction

M. Neukam, P. Sala, A.-D. Brunner, K. Ganss, A. Palladini, M. Grzybek, J. Vasiljevic, J. Broichhagen, U. Coskun, K. Johnsson, T. Kurth, M. Mann, M. Solimena

The paper purifies age-distinct insulin secretory granules from INS-1 cells and identifies age-related changes in their lipid composition and membrane properties.

bioRxiv · Jun 3, 2020Cell Biology

Recapitulating evolutionary divergence in a single regulatory element causes expression changes of the lens gene Tdrd7

J. G. Roscito, K. Subramanian, R. Naumann, M. Sarov, A. Shevchenko, A. Bogdanova, T. Kurth, L. Forster, M. Kreysing, M. Hiller

The paper investigates how mutations in a regulatory element upstream of Tdrd7 affect lens development by replacing the mouse sequence with the blind mole rat sequence in mice.

bioRxiv · Mar 22, 2020Evolutionary Biology

Zebrafish spinal cord repair is accompanied by transient tissue stiffening

S. Möllmert, M. Kharlamova, T. Hoche, A. V. Taubenberger, S. Abuhattum, V. Kuscha, T. Kurth, M. Brand, J. Guck

This study measures tissue stiffness changes in zebrafish spinal cord during repair, finding transient stiffening that correlates with cellular and structural changes.

bioRxiv · Jun 11, 2019Biophysics

3D microenvironment stiffness regulates tumor spheroid growth and mechanics via p21 and ROCK

A. V. Taubenberger, S. Girardo, N. Traber, E. Fischer-Friedrich, M. Krater, K. Wagner, T. Kurth, I. Richter, B. Haller, M. Binner, D. Hahn, U. Freudenberg, C. Werner, J. Guck

This study shows that 3D microenvironment stiffness affects tumor spheroid growth and mechanics through p21 and ROCK pathways.

bioRxiv · Mar 23, 2019Bioengineering

Acute but not inherited demyelination in mouse models leads to brain tissue stiffness changes

D. Eberle, G. Fodelianaki, T. Kurth, A. Jagielska, S. Moellmert, E. Ulbricht, K. Wagner, A. V. Taubenberger, N. Traeber, J.-C. Escolano, R. Franklin, K. J. Van Vliet, J. Guck

This study shows that acute demyelination reduces brain tissue stiffness, while inherited demyelination does not, potentially affecting remyelination in mouse models.

bioRxiv · Nov 5, 2018 · PreprintBiophysics