M. Do

Mechanical evolution of metastatic cancer cells in three-dimensional microenvironment

This study uses optical Brillouin microscopy to analyze mechanical features of cancer spheroids over time, showing improved classification accuracy using these features.

Glycolysis Fuels Phosphoinositide 3-Kinase Signaling to Bolster T Cell Immunity

This study shows that glycolysis fuels PI3K signaling in CD8+ T cells, linking metabolic reprogramming to T cell immunity and suggesting therapeutic targets for infectious diseases and cancer.

Strong intracellular signal inactivation produces sharper and more robust signaling from cell membrane to nucleus

The paper models how signal inactivation sharpens and stabilizes chemical signal propagation through the cytosol by filtering non-geodesic paths in human B cells.

IRF8 Governs Tumor-Associated Macrophage Control of T Cell Exhaustion

This study identifies IRF8 as a key factor in tumor-associated macrophages (TAMs) that induce T cell exhaustion by presenting cancer antigens, and shows its association with poor patient survival in renal cell carcinoma.

TGFβ Suppresses Type 2 Immunity to Cancer

This study shows that blocking TGFβ signaling in CD4+ T cells enhances type 2 immunity, promoting tumor healing and halting cancer progression through IL-4-mediated vasculature repair.

Antibiotic degradation by commensal microbes shields pathogens

This study shows that commensal bacteria producing beta-lactamase enzymes can degrade antibiotics, protecting pathogens from their effects.

Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors

This study identifies structural instability and divergence from conserved residues as causes of intracellular retention of odorant receptors, using computational and experimental methods.