R. H. Friedline

This paper uses CRISPR to enhance browning of human adipocytes, improving metabolic health in mice without immunogenic Cas9 exposure.

This study characterizes double-chain viral insulin-like peptides (dcVILPs) and shows they stimulate glucose uptake in white adipose tissue in mice with higher efficacy than insulin.

This study analyzes indirect calorimetry data from thousands of mice to identify sources of metabolic variation and provides guidelines for designing and reporting metabolic experiments.

This study develops CRISPR delivery particles (CriPs) for efficient gene editing in cultured cells and in vivo, demonstrating their potential for therapeutic applications in metabolic disease.