Author

F. Henriques

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cell Biology· 2 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 6 Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 3 Approach:genetic perturbation / CRISPR· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

A. Guilherme· 4 shared M. Kelly· 4 shared M. P. Czech· 4 shared A. H. Bedard· 2 shared B. Yenilmez· 2 shared E. Tsagkaraki· 2 shared J. K. Kim· 2 shared P. Knobl· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersBioengineering

A. Guilherme

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Pathological beige remodeling induced by cancer cachexia depends on the disease severity and involves mainly the trans-differentiation of mature white adipocytes

K. B. N. H. Santos, P. Knobl, F. Henriques, M. A. Lopes, F. O. Franco, L. L. Bueno, S. R. Farmer, M. Batista

This study investigates beige remodeling in cancer cachexia, showing it depends on disease severity and involves transdifferentiation of mature white adipocytes.

bioRxiv · Sep 18, 2023 · PreprintCell Biology

CRISPR-enhanced human adipocyte 'browning' as cell therapy for metabolic disease

E. Tsagkaraki, S. Nicoloro, T. De Souza, J. Solivan-Rivera, A. Desai, Y. Shen, M. Kelly, A. Guilherme, F. Henriques, R. Ibraheim, N. Amrani, K. Luk, S. Maitland, R. H. Friedline, L. Tauer, , M. P. Czech

This paper uses CRISPR to enhance browning of human adipocytes, improving metabolic health in mice without immunogenic Cas9 exposure.

bioRxiv · Oct 13, 2020Bioengineering

Single Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis

F. Henriques, A. H. Bedard, A. Guilherme, M. Kelly, J. Chi, P. Zhang, L. M. Lifshitz, K. Bellve, L. Rowland, B. Yenilmez, S. Kumar, Y. Wang, J. Luban, L. S. Weinstein, J. D. Lin, , M. P. Czech

This study shows that adipocyte signals can drive iWAT browning through macrophage-like cells, independent of sympathetic nerves.

bioRxiv · May 4, 2020Physiology

Toll-Like Receptor-4 Disruption Suppresses Adipose Tissue Remodeling and Increases Survival During Cancer Cachexia Syndrome

F. Henriques, M. Lopes, F. Franco, P. Knobl, K. Santos, L. Bueno, V. Correa, A. Bedard, A. Guilherme, A. Birbrair, S. Peres, S. Farmer, M. L. Batista

This study shows that disrupting TLR4 reduces adipose tissue remodeling and improves survival in cancer cachexia by inhibiting inflammation and macrophage infiltration.

bioRxiv · Aug 25, 2018Cancer Biology

CRISPR delivery particles for developing therapeutic strategies in metabolic disease

Y. Shen, J. L. Cohen, S. M. Nicoloro, M. Kelly, B. Yenilmez, F. Henriques, E. Tsagkaraki, Y. J. K. Edwards, X. Hu, R. H. Friedline, J. K. Kim, M. P. Czech

This study develops CRISPR delivery particles (CriPs) for efficient gene editing in cultured cells and in vivo, demonstrating their potential for therapeutic applications in metabolic disease.

bioRxiv · Jun 21, 2018Bioengineering

Neuronal Modulation of Brown Adipose Activity Through Perturbation of White Adipocyte Lipogenesis

A. Guilherme, D. J. Pedersen, F. Henriques, A. H. Bedard, E. Henchey, M. Kelly, K. Rahmouni, D. A. Morgan, M. P. Czech

This study shows that white adipocyte lipogenesis influences brown adipose thermogenesis through neuronal signaling.

bioRxiv · May 16, 2018Cell Biology