R. Jockers

Design and validation of the first family of photo-activatable ligands for melatonin receptors

The paper designs and validates a family of photo-activatable melatonin ligands to study receptor activation with high temporal resolution.

Novel repertoire of tau biosensors to monitor pathological tau transformation and seeding activity in living cells

This paper develops tau biosensors using Nanoluciferase technology to monitor tau conformational changes and seeding activity in living cells, identifying potential therapeutic targets for tauopathies.

Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vessels

This study shows melatonin and its derivatives prevent SARS-CoV-2 brain entry and reduce cerebral damage in a mouse model.

Acylation of the incretin peptide exendin-4 directly impacts GLP-1 receptor signalling and trafficking

This study compares exendin-4 and its acylated variant exendin-4-C16, showing acylation affects GLP-1R signaling bias, trafficking, and pharmacokinetics.

Signal bias at glucagon family receptors: rationale and downstream impacts

The paper investigates signal bias at glucagon family receptors, showing biased agonists affect intracellular signaling and insulin secretion differently.