R. Lodha

B cell repertoire sequencing of HIV-1 pediatric elite-neutralizers identifies multiple broadly neutralizing antibody clonotypes

This study identifies multiple broadly neutralizing antibody clonotypes in HIV-1 infected pediatric twins using BCR sequencing, showing ongoing development in one twin but not the other.

Recognition determinants of improved HIV-1 neutralization by a heavy chain matured pediatric antibody

This study characterizes a matured HIV-1 broadly neutralizing antibody from a pediatric donor, showing improved neutralization breadth and potency through structural analysis.

Immunophenotyping and transcriptional profiling of human plasmablasts in dengue.

This study characterizes plasmablasts in dengue patients from India, showing their transcriptional features, adhesion molecule expression, and differential expansion based on infection severity.

Identification and characterization of novel infection associated transcripts in macrophages

The paper identifies and characterizes novel infection-associated transcripts in macrophages induced by Mtb and BCG, highlighting their role in the immune response.

Plasma neutralizing antibodies in an infant with interclade HIV-1 superinfection preferentially neutralize superinfecting HIV-1 strains

This study examines nAb responses in an infant with interclade HIV-1 superinfection, finding that neutralizing antibodies primarily target the superinfecting strain and depend on glycans.

A rare mutation in an infant derived HIV-1 envelope glycoprotein alters interprotomer stability and susceptibility to broadly neutralizing antibodies targeting the trimer apex

The paper identifies a rare L184F mutation in HIV-1 Env that destabilizes the trimer apex, leading to escape from broadly neutralizing antibodies targeting the V2 apex.

Broadly neutralizing plasma antibodies effective against diverse autologous circulating viruses in infants with multivariant HIV-1 infection.

The paper identifies viral factors associated with early broadly neutralizing antibody (bnAb) responses in HIV-1-infected infants and suggests implications for polyvalent vaccination strategies.

Viral characteristics associated with sustenance of elite neutralizing activity in chronically HIV-1C infected monozygotic pediatric twins

This study compares viral characteristics in two HIV-1C infected monozygotic twins with differing elite neutralizing antibody profiles, identifying viral mutations associated with neutralization resistance and susceptibility.

An HIV-1 broadly neutralizing antibody from a clade C infected pediatric elite neutralizer potently neutralizes the contemporaneous and autologous evolving viruses

This study isolates and characterizes an HIV-1 broadly neutralizing antibody from a pediatric elite neutralizer, showing potent neutralization of cross-clade and autologous viruses.