D. Shi

Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis

This study shows metformin reduces hepatic ischemia/reperfusion injury by altering gut microbiota to increase GABA, which inhibits ferroptosis.

Ferroptosis induced by phenolic compound-iron complex

This study shows phenolic compounds induce ferroptosis via iron complex formation, leading to cell death in bacteria and mammals, with potential therapeutic and biotechnological applications.

Strigolactones optimise plant water usage by modulating vessel formation

The paper identifies strigolactone signaling's role in modulating vessel element formation in Arabidopsis, enhancing drought resistance by altering water transport efficiency.

Generative Molecular Design and Experimental Validation of Selective Histamine H1 Inhibitors

The paper develops a generative molecular design platform, ATOM-GMD, to create selective histamine H1 inhibitors, which are validated experimentally with six compounds showing high potency and selectivity.

Effects of structural complexity and water depth on the juvenile blue crab Callinectes sapidus in a simulated salt marsh mesocosm

This study examines how structural complexity and water depth affect juvenile blue crab survival in a simulated salt marsh mesocosm, finding that shoot density increases survival while water depth does not.

Hepatic AMPK activation in response to dynamic REDOX balance is a biomarker of exercise to improve blood glucose control

The paper compares exercise and antioxidant intervention in type 2 diabetic rats, showing both improve blood glucose via hepatic AMPK activation and redox balance, with exercise promoting moderate ROS for AMPK activation.

In situ architecture and membrane fusion of SARS-CoV-2 Delta variant

The paper reports the in situ structure of SARS-CoV-2 Delta variant virions and captures membrane fusion snapshots, revealing unique architectural features and fusion mechanisms.

5-aminolevulinic acid-photodynamic therapy ameliorates cutaneous granuloma by killing drug-resistant Mycobacterium marinum

This study shows that ALA-PDT kills drug-resistant M. marinum in vitro and in a mouse model, leading to recovery of cutaneous lesions and clinical improvement in two patients.

Strigo-D2 - a bio-sensor for monitoring the spatio-temporal pattern of strigolactone signaling in intact plants

The paper introduces Strigo-D2, a genetically encoded sensor to monitor strigolactone signaling in plants, showing differential dynamics across cell types.

Protein phosphatase 1 regulatory inhibitor subunit 14C promotes triple-negative breast cancer progression via sustaining inactive glycogen synthase kinase 3 beta

This study identifies PPP1R14C as a driver of triple-negative breast cancer progression by inactivating GSK3β through PP1 inhibition and TRIM25-mediated degradation of non-phosphorylated GSK3β.

Valid statistical approaches for clustered data: A Monte Carlo simulation study

This study evaluates the impact of incorrect statistical modeling of nested data in preclinical research using Monte Carlo simulations, showing increased type 1 error and bias when using fixed effects ANOVA instead of random effects ANOVA.

Molecular architecture of the SARS-CoV-2 virus

This study reveals the molecular architecture of the SARS-CoV-2 virus using cryo-ET and STA, showing the structure of S proteins, N-linked glycans, and RNPs.

Celsr1 and CAMSAP3 differently regulate intercellular and intracellular cilia orientation in oviduct multiciliated cells

This study shows Celsr1 and CAMSAP3 regulate BB orientation in MCCs differently, with CAMSAP3 critical for intracellular coordination and Celsr1 dispensable for individual cell orientation.

A novel pathway controlling cambium initiation and -activity via cytokinin biosynthesis in Arabidopsis

This study identifies AHL15 as a key regulator of vascular cambium activity and secondary xylem formation in Arabidopsis through cytokinin biosynthesis.

Antineoplastic kinase inhibitors: a new class of potent anti-amoebic compounds

This study identifies six FDA-approved antineoplastic kinase inhibitors with potent anti-amoebic activity against Entamoeba histolytica, including one drug effective against both trophozoites and cysts.

Tissue-specific transcriptome profiling of the Arabidopsis thaliana inflorescence stem reveals local cellular signatures.

The paper establishes a genome-wide high-resolution gene expression map of the Arabidopsis thaliana inflorescence stem, identifying tissue-specific cellular signatures and transcriptional regulators.

The acetyltransferase Eco1 elicits cohesin dimerization during S phase

This study shows that Eco1-mediated acetylation promotes cohesin dimerization during S phase, which is regulated by Hos1 and Wpl1.

Reclassification of SLC22 Transporters: Analysis of OAT, OCT, OCTN, and other Family Members Reveals 8 Functional Subgroups

This paper reclassifies SLC22 transporters into 8 functional subgroups using GWAS, in vivo models, and in vitro assays, revealing shared substrate specificity and subgroup associations.

OBERON3 and SUPPRESSOR OF MAX2 1-LIKE proteins form a regulatory module specifying phloem identity

The paper identifies OBERON3 and SUPPRESSOR OF MAX2 1-LIKE proteins as a regulatory module that establishes phloem identity in Arabidopsis thaliana through chromatin remodeling and gene expression.

Large-scale Analysis of 2,152 dataset reveals key features of B cell biology and the antibody repertoire

This study analyzes 2,152 antibody repertoires to identify key features of B cell biology, revealing gene usage patterns, sex preferences, and mutability mechanisms in the antibody repertoire.

Structure determination from lipidic cubic phase embedded microcrystals by MicroED

This study demonstrates the use of modified LCP and MicroED protocols to determine structures from microcrystals embedded in LCP using proteinase K as a model system.

A receptor for herbivore-associated molecular patterns mediates plant immunity

The paper identifies a plant receptor that detects herbivore-associated peptides, enhancing defense against caterpillars.

Ascitic bacterial composition is associated with clinical outcomes in cirrhotic patients with culture-negative and nonneutrocytic ascites

The paper analyzes ascitic microbiota composition in cirrhotic patients and finds two microbial clusters associated with different clinical outcomes, particularly higher short-term mortality in one cluster.

Analysis of global and site-specific radiation damage in cryo-EM

The paper analyzes radiation damage in cryo-EM using MicroED, finding similar damage dynamics to X-ray crystallography, including metal ion perturbation and disulfide bond breaking.

MicroED Structures of HIV-1 Gag CTD-SP1 Reveal Binding Interactions with the Maturation Inhibitor Bevirimat

The paper uses MicroED to determine the structure of HIV-1 Gag CTD-SP1 with bevirimat, revealing binding interactions that inform drug discovery.