BiophysicsbioRxiv
The Dynamic Conformational Landscapes of the Protein Methyltransferase SETD8
S. Chen, R. P. Wiewiora, F. Meng…·M. Luo
This study reveals dynamic conformational landscapes of SETD8 using X-ray structures and molecular simulations, showing how protein dynamics influence catalysis and cancer-associated mutations.
DOI 10.7554/elife.45403