C. Luo

Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination

This study identifies potent and broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses from a vaccinated donor, showing their efficacy against multiple variants and providing insights for therapeutic development.

Not dasycladalean alga, but an Odyssey of the earliest Phanerozoic animal reef-builders

The paper reclassifies Protomelission? sp. as archaeocyath-like sponges, challenging previous interpretations and providing insights into early animal reef-building.

A peptide-centric local stability assay to unveil protein targets of diverse ligands

This paper introduces PELSA, a peptide-centric local stability assay that identifies ligand-binding regions across the proteome with high sensitivity and without ligand modification.

Immunities Specific to Both of the M Protein Ectodomain and RBD Synergize to Confer Cross-protection against SARS-CoV-2 Infections

This study identifies conserved M protein peptides that elicit cross-neutralizing antibodies against multiple SARS-CoV-2 variants, including Omicron, when combined with RBD-specific antibodies.

Brd4-Nutm1 fusion gene initiates NUT carcinoma in vivo

This study creates a genetically engineered mouse model of NUT carcinoma by inducing the Brd4::Nutm1 fusion gene, showing it can initiate aggressive tumors with features similar to human NC.

Target Identification and Mechanistic Characterization of Indole Terpenoid Mimics: Proper Spindle Microtubule Assembly Is Essential for Cdh1-Mediated Proteolysis of CENP-A

The paper identifies microtubule-targeting agents that induce CENP-A accumulation by destabilizing Cdh1, linking microtubule dynamics to CENP-A proteolysis.

Long-term citizen science data reveals environmental correlates of tropical tree flowering at the regional scale

The paper uses citizen science data to analyze environmental factors influencing flowering patterns of three tree species in Kerala, finding species-specific and habitat-dependent associations with climate variables.

Widespread mermithid nematode parasitism of Cretaceous insects

This study describes 16 new mermithid nematode fossils from mid-Cretaceous amber, revealing widespread parasitism of invertebrates and new host associations.

The velvet family proteins mediate low resistance to isoprothiolane in Magnaporthe oryzae

This study identifies MoVelB, a velvet family transcription factor, as a determinant of low IPT resistance in M. oryzae by deforming the LaeA-VeA-VelB heterotrimer and down-regulating secondary metabolism and CYP450 genes.

The critical role of BTRC in hepatic steatosis as an ATGL E3 ligase

This study identifies BTRC as an E3 ligase that promotes ATGL proteasomal degradation, contributing to hepatic steatosis in NAFLD, and suggests BTRC as a potential therapeutic target.

Inflammation-Responsive Micellar Nanoparticles from Degradable Polyphosphoramidates for Targeted Delivery to Myocardial Infarction

This paper develops biodegradable micellar nanoparticles responsive to inflammation, showing targeted accumulation in myocardial infarction sites in rats.

Identification and current palaeobiological understanding of "Keratosa"-type non-spicular demosponge fossils in carbonates: with a new example from the lowermost Triassic, Armenia

The paper identifies and analyzes non-spicular demosponge fossils from the lowermost Triassic in Armenia, proposing criteria for their recognition and discussing their evolutionary significance.

LncRNA Malat1 represses Th17 effector program by maintaining a critical bivalent super-enhancer and promotes intestinal inflammation

This study shows that lncRNA Malat1 restricts Th17 cell IL-17A production by regulating a bivalent super-enhancer, thereby controlling intestinal inflammation resolution.

Enzyme-Responsive Nanoparticles for the Targeted Delivery of an MMP Inhibitor to the Heart post Myocardial Infarction

This paper develops enzyme-responsive nanoparticles that deliver an MMP inhibitor to the heart after myocardial infarction, showing targeted retention and controlled drug release.

The SARS-CoV-2 Omicron (B.1.1.529) variant exhibits altered pathogenicity, transmissibility, and fitness in the golden Syrian hamster model

The study compares the pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron and Delta variants in golden Syrian hamsters, finding Omicron less pathogenic but more transmissible and capable of outcompeting Delta under immune pressure.

SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

This study shows SARS-CoV-2 infection causes bone loss in golden Syrian hamsters through cytokine dysregulation and osteoclastogenesis.

Imaging the ultrastructures and dynamics of live erythrocyte membranes at the single-molecule level with a far-red probe on a microfluidic platform

This study develops a far-red probe and microfluidic platform to image live erythrocyte membranes at the single-molecule level, enabling high-throughput super-resolution and tracking.

Late Anisian microbe-metazoan build-ups ('stromatolites') in the Germanic Basin -- aftermath of the Permian -- Triassic Crisis

This paper analyzes late Anisian stromatolites from the Germanic Basin, revealing they are microbe-metazoan build-ups formed by microbes and non-spicular demosponges, not purely microbial structures.

Response of whitefly to the wild tomato Solanum habrochaites

This study examines how the wild tomato Solanum habrochaites affects the survival, fecundity, and gene expression of the whitefly Bemisia tabaci, revealing stress gene induction and potential for pest control.

Revisiting the phosphorite deposit of Fontanarejo (central Spain): new window into the early Cambrian evolution of sponges and into the microbial origin of phosphorites

The paper examines Cambrian phosphorites in Spain, revealing microbial processes in phosphatization and early sponge evolution.

Double Lock of a Potent Human Monoclonal Antibody against SARS-CoV-2

This paper identifies and characterizes a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 receptor binding and membrane fusion, showing protective effects in mice and non-adverse effects in rhesus macaques.

The APETALA2 transcription factor LsAP2 regulates seed shape in lettuce

This study identifies LsAP2 as a transcription factor regulating seed shape in lettuce, showing its role in seed development and dispersal through interactions with LsBP and involvement in brassinosteroid pathways.

Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD+, Suppresses Glycolysis, TCA Cycle and Cell Growth

This study shows NMNH enhances NAD+ and inhibits glycolysis, TCA cycle, and cell growth, but does not affect mice.

Nudging the N170 forward with prior stimulation - Bridging the gap between N170 and recognition potential

This study shows that manipulating the ISI can transform the N170 into an RP, suggesting that morphology-based classification of ERP components may not be reliable when using forward masks.

A small molecule screen identified N-Acetyl-L-cysteine for promoting ex vivo growth of single circulating tumor cells

The paper identifies N-acetylcysteine (NAC) as a compound that promotes ex vivo growth of single circulating tumor cells by reducing oxidative stress.

Time-course transcriptome landscape of achene development in lettuce

This study performs a time-course transcriptome analysis of lettuce achenes to identify gene expression patterns and molecular mechanisms during achene development.

Injectable Myocardial Matrix Hydrogel Mitigates Negative Left Ventricular Remodeling in a Chronic Myocardial Infarction Model

This study investigates how a myocardial matrix hydrogel reduces negative left ventricular remodeling in chronic myocardial infarction by modulating immune response and gene expression.

Myocardial matrix material supports a proliferative microenvironment for cardiomyocytes

This study shows that myocardial matrix hydrogel promotes cardiomyocyte proliferation by scavenging ROS and supporting cell cycle progression in vitro and in vivo.

Consensus Finder web tool to predict stabilizing substitutions in proteins

Consensus Finder predicts stabilizing protein substitutions by identifying frequently occurring amino acids in homologous sequences.

Histone deacetylase inhibitor givinostat attenuates nonalcoholic steatohepatitis and liver fibrosis

This study evaluates givinostat's efficacy in treating NASH by reducing inflammation and fibrosis in mouse models.