The Dynamic Conformational Landscapes of the Protein Methyltransferase SETD8
S. Chen, R. P. Wiewiora, F. Meng, N. Babault, A. Ma, W. Yu, K. Qian, H. Hu, H. Zou, J. Wang, S. Fan, G. Blum, F. Pittella-Silva, K. A. Beauchamp, W. Tempel, , M. Luo
This study reveals dynamic conformational landscapes of SETD8 using X-ray structures and molecular simulations, showing how protein dynamics influence catalysis and cancer-associated mutations.
bioRxiv · Oct 12, 2018Biophysics