S. Abraham

Stablization of Interdomain Interactions in G protein αi Subunits Determines Gαi Subtype Signaling Specificity

This study identifies an amino acid difference that stabilizes interdomain interactions in Gi1 but not Gi2, leading to differences in effector activation and signaling specificity.

Escherichia coli isolated from commercial layer hens in Australia remain susceptible to critically important antimicrobials

This study assesses antimicrobial resistance in Escherichia coli from Australian layer hens, finding low resistance rates likely due to strict antimicrobial use controls.

Antimicrobial Resistance, Genomic, and Public Health Insights into Enterococcus spp. from Australian Cattle

This study examines antimicrobial resistance in enterococci from Australian cattle and finds low resistance prevalence, with bovine isolates clustering with non-vancomycin-resistant human isolates.

Proximity to human settlement is directly related to carriage of critically important antimicrobial-resistant Escherichia coli and Klebsiella pneumoniae in Silver Gulls

This study finds that Silver Gulls near human settlements carry more critically important antimicrobial-resistant E. coli and K. pneumoniae than those in remote areas.

Identification of G Protein αi Signaling Partners by Proximity Labeling Reveals a Network of Interactions that Includes PDZ-RhoGEF

The paper identifies G protein αi signaling partners using proximity labeling, revealing a network including PDZ-RhoGEF and functional differences among Gi isoforms.

Validation of selective agars for detection and quantification of Escherichia coli resistant to critically important antimicrobials

This study identifies optimal selective agars and antimicrobial combinations for detecting and quantifying resistant Escherichia coli using designed experiments and statistical analysis.

Robotic Antimicrobial Susceptibility Platform (RASP): A Next Generation Approach to One-Health Surveillance of Antimicrobial Resistance.

The paper introduces a robotic platform for high-throughput antimicrobial resistance surveillance, showing it matches human performance and identifies diverse AMR phenotypes in gut E. coli.

BRD4-mediated repression of p53 is a target for combination therapy in AML

This study shows that combining MDM2 inhibitors and BET inhibitors synergistically kills AML cells by enhancing p53 activation through BRD4's repressive function.

Bursting out: linking changes in nano-topography and biomechanical properties of biofilm-forming Escherichia coli to T4 lytic cycle

This study investigates how T4 phage infection alters the nano-topography and biomechanics of biofilm-forming E. coli, revealing distinct lysis patterns compared to planktonic cells.

Challenges and Strategies for Recruiting Type 1 Diabetes Families in Kuwait with Strong Beliefs in Familism

This paper describes strategies for recruiting T1D families in Kuwait, emphasizing cultural sensitivity and tailored approaches to overcome familial and religious barriers.

Examination of Australian Streptococcus suis Isolates From Clinically Affected Pigs in a Global Context and the Genomic Characterisation of ST1 as a Predictor of Virulence

The paper analyzes 148 Australian Streptococcus suis isolates from pigs, comparing their genomic features and virulence genes to global isolates, identifying ST1 as a virulence predictor.

HNF1A is a Novel Oncogene and Central Regulator of Pancreatic Cancer Stem Cells

This study identifies HNF1A as a central regulator of pancreatic cancer stem cells and a novel oncogene in pancreatic ductal adenocarcinoma.