EZH2 deletion does not impact acinar cell regeneration but restricts progression to pancreatic cancer in mice
E. Jaune-Pons, X. Wang, F. Mousavi, A. El kaoutari, K. Berger, C. Johnson, M. Martin, S. Aggarwal, S. Brar, K. Muhammad, P. Shooshtari, A. Mathison, N. Dusetti, R. Urrutia, G. Lomberk, C. L. Pin
This study shows EZH2 deletion in adult acinar cells does not block regeneration but limits PDAC progression by altering the tumor microenvironment and differentiation.
bioRxiv · Sep 25, 2023 · PreprintCancer Biology