CD244 regulates both innate and adaptive immune axes in melanoma by inhibiting autophagy-mediated M1 macrophage maturation
J. Kim, T.-J. Kim, S. Chae, S. Park, H. Ha, Y. Park, C. J. Yoon, J. Kim, J. Kim, K. Im, H. Lee, K. Lee, J. Kim, D. Kim, E. Lee, , K.-M. Lee
This study shows CD244 inhibits macrophage maturation in melanoma, enhancing T cell responses and improving tumor rejection when combined with PD-L1 blockade.
bioRxiv · Dec 1, 2022 · PreprintImmunology