S. Sheng

Proteolytic Cleavage of the ENaC gamma Subunit: Impact Upon Na+ and K+ Handling

This study investigates the impact of proteolytic cleavage of the ENaC gamma subunit on Na+ and K+ handling in mice, finding that cleavage is not essential for channel activity in vivo.

Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression

This study shows that inhibiting subchondral osteoclastogenesis maintains hypoxia in subchondral bone, slowing osteoarthritis progression by stabilizing HIF-1 and reducing cartilage degeneration.

Phototherapy with physically and molecularly produced light for Alzheimer's disease

This study shows that combining a photolabile Aβ ligand with LED or molecular light can reduce Aβ accumulation in mice, suggesting a new phototherapy approach for Alzheimer's disease.

Water and Electrolyte Homeostasis in a Mouse Model with Reduced ENaC Gamma Subunit Expression

This study examines the role of the ENaC gamma subunit in electrolyte and fluid homeostasis using a mouse model with reduced gamma subunit expression, finding altered responses to dietary changes and fluid balance.

Large-scale sequence similarity analysis reveals the scope of sequence and function divergence in PilZ domain proteins

This study analyzes over 28,000 PilZ domain proteins using sequence similarity networking to uncover sequence-function relationships and functional diversification across the superfamily.