Author

S. Gaffen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 5 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

D. H. Kaplan· 2 shared D.-D. Li· 2 shared P. S. Biswas· 2 shared R. Bechara· 2 shared S. Gingras· 2 shared T. Edwards· 2 shared Y. Li· 2 shared A. Liu· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

D. H. Kaplan

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

EGFR-MAPK adaptor proteins mediate the epithelial response to Candida albicans via the cytolytic peptide toxin, candidalysin

N. O. Ponde, L. Lortal, A. Tsavou, O. W. Hepworth, D. Wickramansinghe, J. Ho, J. Richardson, D. Moyes, S. Gaffen, J. R. Naglik

This study identifies EGFR-MAPK adaptor proteins that mediate epithelial responses to C. albicans via candidalysin, showing their role in ERK1/2 signaling and cytokine production.

bioRxiv · Mar 5, 2022 · PreprintMicrobiology

Arid5a mediates an IL-17-dependent pathway that drives autoimmunity but not antifungal host defense

T. C. Taylor, Y. Li, D.-D. Li, S. Majumder, M. J. McGeachy, P. S. Biswas, S. Gingras, S. Gaffen

This study shows Arid5a promotes IL-17-dependent autoimmunity but not antifungal immunity, suggesting targeted therapy could reduce autoimmune side effects.

bioRxiv · Feb 14, 2022Immunology

Regnase-1 deficiency restrains Klebsiella pneumoniae infection by regulation of a Type I interferon response

G. Trevejo-Nunez, L. Fan, B. Lin, F. Aggor, P. Biswas, K. Chen, S. Gaffen

This study shows that Regnase-1 deficiency increases resistance to Klebsiella pneumoniae infection by enhancing Type I interferon responses, despite not affecting bacterial clearance or pro-inflammatory cytokine expression.

bioRxiv · Nov 20, 2021Immunology

Antibody-induced glomerulonephritis is amplified by RTEC-intrinsic IL-17 signaling and restrained by IL-17-mediated induction of the endoribonuclease Regnase-1 (Zc3h12a)

D.-D. Li, R. Bechara, K. Ramani, C. Jawale, Y. Li, J. Kolls, S. Gaffen, P. S. Biswas

This study shows that IL-17 signaling in renal tubular epithelial cells drives antibody-induced glomerulonephritis, and Regnase-1 limits this inflammation by inhibiting IL-17 target genes.

bioRxiv · Jan 11, 2021 · PreprintImmunology

A loss-of-function mutation in IL-17F enhances susceptibility of mice to oropharyngeal candidiasis

C. Zhou, L. Monin, R. Gordon, F. E. Aggor, R. Bechara, T. Edwards, D. H. Kaplan, S. Gingras, s. gaffen

This study shows that a loss-of-function mutation in IL-17F increases susceptibility to oropharyngeal candidiasis in mice, but not in heterozygous carriers.

bioRxiv · Apr 9, 2020Immunology

Extracellular ATP released from Candida albicans activates non-peptidergic neurons to augment host defense

T. Edwards, S. Zhang, A. Liu, J. Cohen, P. Zhou, S. Mogavero, b. hube, j. berman, m.-e. bougnoux, a. mathers, s. gaffen, K. M. Albers, h. r. koeber, b. davis, c. d'enfert, D. H. Kaplan

This study shows that ATP released by Candida albicans activates non-peptidergic neurons to enhance anti-Candida immune responses.

bioRxiv · Jan 27, 2020 · PreprintImmunology