K. Igarashi

Cysteine restriction induces ferroptosis depending on the polyamine biosynthetic pathway in hepatic cancer cells

This study shows that cysteine restriction induces ferroptosis in hepatic cancer cells via the polyamine biosynthetic pathway, but not in normal hepatocytes.

TANK binding kinase 1 promotes BACH1 degradation through both phosphorylation-dependent and -independent mechanisms without relying on heme and FBXO22

Organelle landscape analysis using a multi-parametric particle-based method

The paper introduces a multi-parametric particle-based method to analyze organelle landscapes, enabling visualization of heterogeneous organelle structures and transitional states using fluorescence microscopy and UMAP.

Acquirement of the autonomic nervous system modulation evaluated by heart rate variability in medaka (Oryzias latipes)

This study evaluates autonomic nervous system modulation in unanesthetized adult medaka using heart rate variability, showing frequency-dependent parasympathetic and sympathetic influences.

Distinctive nuclear zone for RAD51-mediated homologous recombinational DNA repair

This study shows RAD51 forms distinctive nuclear zones to facilitate homologous recombination by bridging damaged and intact DNA during repair.

Thermostable mutants of glycoside hydrolase family 6 cellobiohydrolase from the basidiomycete Phanerochaete chrysosporium

This study identifies thermostable mutants of PcCel6A, a glycoside hydrolase family 6 cellobiohydrolase, by analyzing the impact of cysteine residues on thermal stability.

A hydrogen dependent geochemical analogue of primordial carbon and energy metabolism

This paper demonstrates that hydrothermal minerals catalyze CO2 fixation with H2 under alkaline conditions, producing organic compounds similar to the acetyl-CoA pathway.

Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence

The paper shows that SAM depletion leads to adaptive chromatin changes that maintain heterochromatin stability and epigenetic persistence in mice.

Ferroptosis is programmed by the coordinated regulation of glutathione and iron metabolism by BACH1

This study identifies BACH1 as a regulator of ferroptosis by modulating glutathione and iron metabolism, showing its role in myocardial infarction resistance.

The haploinsufficient tumor suppressor Tip60 negatively regulates the oncogenic Aurora B kinase

This study shows Tip60 acetylates AurkB, reducing its stability and activity, suggesting Tip60 downregulation increases AurkB activity in cancer.

Aurora kinase A mediated phosphorylation of mPOU is critical for skeletal muscle differentiation

The paper shows that Aurora kinase A phosphorylates POU6F1 at Ser197, inhibiting its DNA binding and slowing skeletal muscle differentiation.