S. L. Rossi

CD8+ T cell response promotes viral clearance and reduces chances of severe testicular damage in mouse models of long-term Zika virus infection of the testes.

This study shows CD8+ T cells reduce severe testicular damage in mice with long-term Zika virus infection by promoting viral clearance.

Potential of Ilheus virus to emerge

This study develops murine models of Ilheus virus infection and shows Aedes mosquitoes are highly susceptible, suggesting ILHV is poised for emergence in the neotropics.

Immunologically mediated trade-offs shaping transmission of sylvatic dengue and Zika viruses in native and novel non-human primate hosts

This study investigates immunological trade-offs in non-human primate hosts for dengue and Zika viruses, finding that higher viral replication correlates with increased transmission but reduced antibody response.

EPAC regulates von Willebrand factor secretion from endothelial cells in a PI3K/eNOS-dependent manner during inflammation

This study shows EPAC1 regulates vWF secretion from endothelial cells during inflammation via the PI3K/eNOS pathway, with implications for thrombosis control.

Evolution of resistance to fluoroquinolones by dengue virus serotype 4 provides insight into mechanism of action and consequences for viral fitness

This study investigates resistance to fluoroquinolones in dengue virus serotype 4 and finds that resistance mutations affect viral fitness and binding/entry mechanisms.

Old drugs with new tricks: Efficacy of fluoroquinolones to suppress replication of flaviviruses

This study shows fluoroquinolones like enoxacin inhibit flavivirus replication in human cells and reduce ZIKV titer in mouse testes.