Author

S. Laporte

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

A. K. Shukla· 2 shared A. Ranjan· 2 shared H. Dwivedi-Agnihotri· 2 shared M. Baidya· 2 shared M. Chaturvedi· 2 shared R. Banerjee· 2 shared S. Pandey· 2 shared Y. Cao· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

A. K. Shukla

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Author profile →

3 papers

Recent·Most cited

Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody

M. Baidya, M. Chaturvedi, H. Dwivedi-Agnihotri, A. Ranjan, D. Devost, Y. Namkung, T. M. Stepniewski, S. Pandey, M. Baruah, B. Panigrahi, J. Maharana, R. Banerjee, J. Selent, S. Laporte, T. E. Hebert, A. K. Shukla

This paper shows that a synthetic intrabody enhances β-arrestin endosomal trafficking and ERK1/2 activation in a GPCR mutant by promoting an active-like conformation.

bioRxiv · Jan 11, 2022Biochemistry

Decoding Angiotensin II Type 1 Receptor Allosteric Communication to Gq and β-arrestin

A. K. Nivedha, Y. Cao, S. Lee, S. Bhattacharya, S. Laporte, N. Vaidehi

This study identifies residue networks mediating allosteric communication from the Ang II binding site to Gq and β-arrestin2 coupling sites in AT1R, revealing shared and distinct residues that could guide biased ligand design.

bioRxiv · May 17, 2021 · PreprintBiophysics

Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors

S. Pandey, P. Kumari, M. Baidya, R. Kise, Y. Cao, H. Dwivedi-Agnihotri, R. Banerjee, X. Li, C. Cui, J. Lee, K. Kawakami, M. Chaturvedi, A. Ranjan, S. Laporte, T. M. Woodruff, , A. K. SHUKLA

The paper identifies two non-canonical GPCRs, D6R and C5aR2, that exclusively couple to β-arrestins and exhibit distinct GRK preferences and downstream signaling.

bioRxiv · Feb 2, 2021Biochemistry