M. Peckham

A Multiscale approach reveals the molecular architecture of the autoinhibited kinesin KIF5A.

This study uses multiscale techniques to reveal the molecular structure of autoinhibited KIF5A, showing how its C-terminal tail contributes to autoinhibition and how mutations affect this state.

Human light meromyosin mutations linked to skeletal myopathies disrupt the coiled coil structure and myosin head sequestration

This study investigates how mutations in MYH7 and MYH2 genes affect myosin structure and function, finding that they disrupt coiled-coil structure and increase ATP consumption without affecting contractile function.

Exploiting cryo-EM structures of actomyosin-5a to reveal the physical properties of its lever

This study uses cryo-EM and molecular dynamics to determine the structure and physical properties of Myo5a's lever, revealing its working stroke and implications for its walking mechanism.

RNASeq analysis of a Pax3-expressing myoblast clone in-vitro and effect of culture surface stiffness on differentiation.

The paper analyzes RNASeq data from a Pax3-expressing myoblast clone to investigate how culture surface stiffness affects differentiation, finding enhanced myogenic gene expression on softer surfaces.

Nanoscale pattern extraction from relative positions of sparse 3D localisations

The paper introduces a method to extract high-resolution ordered features from localisation microscopy data by analyzing relative molecular positions, applied to infer ultrastructure of various biological structures.

Persistent Chikungunya Virus Replication in Human Cells is Associated with Presence of Stable Cytoplasmic Granules Containing Non-structural Protein 3

This paper identifies stable cytoplasmic granules containing nsP3 in persistently infected CHIKV cells, showing their long-term persistence and implications for chronic disease.