S. Rajagopalan

The paper introduces PATH, a framework to quantify heritability and plasticity of cellular phenotypes in somatic evolution using single-cell data from mouse and human samples.

The paper identifies a metabolic deficiency causing PDIM loss in Mycobacterium tuberculosis and shows how nutrient supplementation can restore PDIM production and virulence.

This study shows NK cells lyse P. falciparum-infected erythrocytes via ADCC, releasing parasitophorous vacuoles that are phagocytosed by monocytes in the presence of immune IgG.

This study shows SapM phosphatase induces phagosome maturation arrest in Mycobacterium tuberculosis and BCG without requiring the ESX-1 secretion system.

The paper identifies peptide-specific binding of KIR receptors to HLA class I complexes, revealing differences in specificity between inhibitory and activating KIRs.

This study shows that adipocyte lipolysis, regulated by Wnt signaling and DPP4, reduces skin fibrosis by modulating ECM homeostasis.

This study identifies a conserved bacterial epitope recognized by HLA-C*05:01 and the NK cell receptor KIR2DS4, suggesting a novel role for NK cells in detecting bacteria.

The paper shows that antibodies from malaria-exposed individuals activate NK cells to lyse infected red blood cells and inhibit parasite growth via ADCC.

This study shows that HLA-C bound peptides influence KIR binding specificity, with KIR2DL1 showing broader peptide tolerance than KIR2DL2/3, and cross-reactive binding being highly peptide selective.