Author

S. Z. Lam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

L. Peng· 2 shared L. Yang· 2 shared L. Ye· 2 shared Q. Lin· 2 shared S. Chen· 2 shared Y. Zhang· 2 shared A. Sanchez· 1 shared J. J. Park· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersImmunology

L. Peng

Mutual co-authors in cluster

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintMar 14, 2023

Perturbomics of tumor-infiltrating NK cells

L. Peng, P. A. Renauer, L. Ye…·S. Chen

This study identifies genetic factors limiting NK cell function in tumors using CRISPR screens and single-cell sequencing, highlighting CALHM2 as a target for improving NK cell-based therapies.

DOI 10.1101/2023.03.14.532653

mousescRNA-seq

𝕏 PostBluesky

BioengineeringbioRxivPreprintMar 14, 2023

Therapeutic immune cell engineering with an mRNA : AAV-Sleeping Beauty composite system

L. Ye, S. Z. Lam, L. Yang…·S. Chen

The paper introduces a composite gene delivery system called MAJESTIC for efficient and stable engineering of therapeutic immune cells, showing improved cell viability and transgene expression compared to existing methods.

DOI 10.1101/2023.03.14.532651

humanCRISPR screen

𝕏 PostBluesky