Author

S.-I. Murtada

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. B. Ramachandra· 4 shared J. D. Humphrey· 4 shared G. Tellides· 3 shared M. Wang· 3 shared Y. Kawamura· 3 shared A. W. Caulk· 2 shared B. Spronck· 2 shared D. T. Braddock· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersBioengineering

A. B. Ramachandra

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Author profile →

5 papers

Recent·Most cited

Smooth Muscle Cell Death Drives an Osteochondrogenic Phenotype and Severe Proximal Vascular Disease in Progeria

S.-I. Murtada, Y. Kawamura, C. Cavinato, M. Wang, A. B. Ramachandra, B. Spronck, G. Tellides, J. Humphrey

This study links smooth muscle cell death to osteochondrogenic changes and vascular disease in progeria, identifying a sequence of pathological events leading to cardiovascular complications.

bioRxiv · Jan 10, 2023 · PreprintBioengineering

Ex Vivo Biomechanical Characterization of Umbilical Vessels: Possible Shunts in Congenital Heart Palliation

S.-I. Murtada, A. B. Ramachandra, J. D. Humphrey

This study biomechanically compares umbilical veins and arteries with subclavian and pulmonary arteries to evaluate their suitability as shunts for congenital heart palliation.

bioRxiv · Jan 7, 2023 · PreprintBioengineering

Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford Progeria Syndrome

S.-I. Murtada, N. Mikush, M. Wang, P. Ren, Y. Kawamura, A. B. Ramachandra, D. T. Braddock, G. Tellides, L. B. Gordon, J. D. Humphrey

Lonafarnib improves cardiovascular function and survival in a progeria mouse model by reducing pulse wave velocity and enhancing left ventricular diastolic function.

bioRxiv · Dec 17, 2021Pathology

Genetic Background Dictates Aortic Fibrosis in Hypertensive Mice

B. Spronck, M. Latorre, S. Mehta, A. W. Caulk, A. B. Ramachandra, S.-I. Murtada, A. Rojas, C.-S. He, B. Jiang, M. Wang, M. R. Bersi, G. Tellides, J. D. Humphrey

This study shows that genetic background strain influences aortic fibrosis in hypertensive mice, with C57BL/6J mice showing more maladaptive remodeling than 129SvEv mice.

bioRxiv · May 5, 2020Bioengineering

Paradoxical Aortic Stiffening and Subsequent Cardiac Dysfunction in Hutchinson-Gilford Progeria Syndrome

S.-I. Murtada, Y. Kawamura, A. W. Caulk, H. Ahmadzadeh, N. Mikush, K. Zimmerman, D. Kavanagh, D. Weiss, M. Latorre, Z. W. Zhuang, G. S. Shadel, D. T. Braddock, J. D. Humphrey

This study shows that aortic stiffening and cardiac dysfunction in HGPS mice occur due to loss of smooth muscle function and proteoglycan accumulation, independent of sex, with potential therapeutic implications.

bioRxiv · Oct 2, 2019Bioengineering