B. Jiang

Shrimp Hemocyanin elicits a potent humoral response in mammals and is favorable to hapten conjugation

This study shows shrimp hemocyanin (SHC) can replace keyhole limpet hemocyanin (KLH) as a carrier protein for hapten conjugation, offering better solubility and comparable immunogenicity in mammals.

Acute BRCAness Induction and AR Signaling Blockage through CDK12/7/9 Degradation Enhances PARP Inhibitor Sensitivity in Prostate Cancer

This paper introduces BSJ-5-63, a PROTAC that degrades CDK12, CDK7, and CDK9, inducing BRCAness and blocking AR signaling to enhance PARP inhibitor sensitivity in prostate cancer.

Gut-resident C. perfringens impedes rotavirus vaccine efficacy

The paper investigates how gut microbiota, particularly C. perfringens, affects rotavirus vaccine efficacy in mice and human children.

Heterogeneous Cardiac- and Neural Crest-Derived Aortic Smooth Muscle Cells have Similar Transcriptional Changes after TGFβ Signaling Disruption

The paper analyzes single-cell transcriptomes of aortic smooth muscle cells in mice to show distinct origins and similar transcriptional changes after TGFβ signaling disruption.

Short-Term Disruption of TGFβ Signaling in Adult Mice Renders the Aorta Vulnerable to Hypertension-Induced Dissection

This study shows that disrupting TGFβ signaling in adult mice makes the aorta susceptible to hypertension-induced dissection, even from short-term blood pressure increases.

A telomere-to-telomere genome assembly of Zhonghuang 13, a widely-grown soybean variety from the original center of Glycine max

This paper presents the first telomere-to-telomere genome assembly of the soybean cultivar Zhonghuang 13, resolving gaps and identifying novel genes and structural variations.

AMPK targets PDZD8 to trigger carbon source shift to glutamine

This paper identifies AMPK's role in shifting carbon utilization from glucose to glutamine via PDZD8 phosphorylation, enhancing glutaminolysis and extending lifespan in C. elegans and mice.

A semi-quantitative, rapid, point of care SARS-CoV-2 serologic assay predicts neutralizing antibody levels

This paper introduces a semi-quantitative lateral flow assay that correlates with neutralizing antibody levels in SARS-CoV-2 recovered individuals.

Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses

The paper identifies acetate as a novel energy stress marker produced in the liver via ACOT12/8-mediated conversion of acetyl-CoA from fatty acids, supporting its role in brain fueling and CoA recycling.

Spatially aware deep learning reveals tumor heterogeneity patterns that encode distinct kidney cancer states

The paper uses spatially aware deep learning to identify tumor heterogeneity patterns in kidney cancer, revealing distinct states associated with different histological subtypes.

Pharmacological modulators of epithelial immunity uncovered by synthetic genetic tracing of SARS-CoV-2 infection responses

The paper identifies pharmacological modulators of epithelial immunity by analyzing SARS-CoV-2 infection responses using synthetic genetic reporters and drug screens.

Logical design of synthetic cis-regulatory DNA for genetic tracing of cell identities and state changes

The paper introduces LSD, a computational framework for designing synthetic cis-regulatory DNA to mark cellular states, and demonstrates its effectiveness in identifying cell-state drivers.

"Double-Effect" strategy against Triple-Negative Breast Cancer via a synergistic therapy of Magneto-mechanical Force enhancing NIR-II Hypothermal Ablation

This paper develops a synergistic therapy for triple-negative breast cancer using magneto-mechanical force and NIR-II hypothermal ablation to suppress tumor migration and invasion.

Intratumoral heterogeneity and clonal evolution induced by HPV integration

This study identifies heterocateny as a structural variation caused by HPV integration, promoting intratumoral heterogeneity and clonal evolution in oropharyngeal cancers.

3D bioprinting of an implantable xeno-free vascularized human skin graft

This paper develops a xeno-free bioprinted vascularized human skin graft using cultured cells and bioinks, showing successful implantation and vascularization in mice.

Horizontal Transfer and Evolution of the Biosynthetic Gene Cluster for Benzoxazinoid

This study identifies horizontal transfer of a biosynthetic gene cluster for benzoxazinoids among grasses, revealing evolutionary mechanisms and selection pressures.

Examining Batch Effect in Histopathology as a Distributionally Robust Optimization Problem

This paper shows that using abstention in a patch-based classifier improves performance in histopathology tasks while reducing reliance on spurious features.

Addressing Enzymatic-Independent Tumor-Promoting Function of NAMPT via PROTAC-Mediated Degradation

This study develops two PROTACs targeting NAMPT, showing they degrade the protein more effectively than FK866 in tumor cells, highlighting PROTACs as a better strategy for dual-function proteins.

Precision Genome and Base Editing by Regulating mRNA Nuclear Export Using Selective Inhibitors of Nuclear Export

This study identifies SINEs as inhibitors of CRISPR-Cas9 activity by blocking Cas9 mRNA nuclear export, enhancing genome and base editing specificity in human cells.

Genetic Background Dictates Aortic Fibrosis in Hypertensive Mice

This study shows that genetic background strain influences aortic fibrosis in hypertensive mice, with C57BL/6J mice showing more maladaptive remodeling than 129SvEv mice.

Targeting the PI5P4K lipid kinase family in cancer using novel covalent inhibitors

This study identifies THZ-P1-2, a covalent pan-PI5P4K inhibitor, showing efficacy in AML/ALL cell lines and autophagy disruption, supporting PI5P4Ks as therapeutic targets in cancer.

Effects of substrate stiffness on the biological behavior of human umbilical vein endothelial cells

This study examines how substrate stiffness affects human umbilical vein endothelial cell behavior, finding increased CX40 and GAG content and decreased actin stress fibers and proliferation on stiff substrates.

Combination of Dynamic Turbidimetry and Tube Agglutination to Identify Procoagulant Genes by Transposon Mutagenesis in Staphylococcus aureus

The paper identifies procoagulant genes in Staphylococcus aureus using transposon mutagenesis combined with tube agglutination and dynamic turbidimetry, finding 8 genes involved in aggregation.

NINJA-Associated ERF19 Negatively Regulates Arabidopsis Pattern-Triggered Immunity

This study identifies ERF19 as a negative regulator of PTI in Arabidopsis, showing that NINJA represses ERF19 to fine-tune immune responses against pathogens.