Negative regulation of APC/C activation by MAPK-mediated attenuation of Cdc20Slp1 under stress
L. Sun, X. Chen, C. Song, W. Shi, L. Liu, S. Bai, X. Wang, J. Chen, C. Jiang, S.-m. Wang, Z.-q. Luo, R. Wang, Y. Wang, Q.-w. Jin
The paper shows that MAPK Pmk1 in fission yeast inhibits APC/C activation by phosphorylating and degrading Slp1Cdc20 under stress, revealing a conserved regulatory mechanism.
bioRxiv · Apr 2, 2024Cell Biology