T. Arnold

Structural and molecular basis of choline uptake into the brain by FLVCR2

This study identifies FLVCR2 as the primary choline transporter at the blood-brain barrier, determines its structures, and elucidates its mechanism of choline uptake.

SARS-CoV-2 Protein Nsp2 Stimulates Translation Under Normal and Hypoxic Conditions

This study shows that SARS-CoV-2 protein Nsp2 enhances both cap- and IRES-dependent translation under normal and hypoxic conditions, particularly for mRNAs reliant on eIF4F.

MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4 γ- dependent transcription of CES enzymes

This study identifies CES1D as the hydrolase downstream of the MFGE8-vβ5 integrin pathway that regulates catabolism of diet-derived lipid droplets in enterocytes.

Alk1 mutant endothelial cells undergo clonal expansion in mouse brain arteriovenous malformations

This study shows that Alk1 mutant endothelial cells expand clonally in mouse brain arteriovenous malformations (AVMs) and that BM-derived Alk1 mutant ECs can cause AVMs.