L. Fischer

SPT6L, a newly discovered ancestral component of the plant RNA-directed DNA methylation pathway

This paper identifies SPT6L as a conserved AGO-hook protein in the plant RdDM pathway, showing its role in chromatin dynamics and DNA methylation.

Highly synchronized cortical circuit dynamics mediate spontaneous pain

This study shows that spontaneous pain induces synchronized neural dynamics in the primary somatosensory cortex, and reversing this synchronization alleviates pain.

Serological screening in wild ruminants in Germany, 2021/22: No evidence of SARS-CoV-2, bluetongue virus or pestivirus spread but high seroprevalences against Schmallenberg virus

The paper serologically screens wild ruminants in Germany for SARS-CoV-2, bluetongue virus, pestivirus, and Schmallenberg virus, finding no evidence of spread but high seroprevalence against Schmallenberg virus and potential cross-reactivity with SARS-CoV-2.

Viscoelastic properties of suspended cells measured with shear flow deformation cytometry

This paper introduces a microfluidic method to measure viscoelastic properties of suspended cells using shear flow deformation cytometry and demonstrates cell cycle-dependent rheological behavior.

BNT162b vaccines are immunogenic and protect non-human primates against SARS-CoV-2

This paper evaluates two BNT162b vaccine candidates in non-human primates, showing they are immunogenic and protect against SARS-CoV-2 infection.

In vitro and in silico modeling of cellular and matrix-related changes during the early phase of osteoarthritis

This study combines in vitro and in silico models to simulate early osteoarthritis changes, showing inflammation-induced matrix degradation and partial reversibility.

An integrated workflow for cross-linking/mass spectrometry

The paper introduces a workflow combining sequential digestion and Xi software to improve cross-linking mass spectrometry detection of protein interactions.

Defining the RNA Interactome by Total RNA-Associated Protein Purification

This paper introduces TRAPP, a method to identify RNA-binding proteins genome-wide, and demonstrates its application in yeast and bacteria, revealing novel RNA-protein interactions and their changes under stress.