T. Hiraiwa

This study identifies a mechanism where invading cells and tissue barriers coordinate to rupture barriers through intercellular adhesions and subcellular contractility, challenging existing models of collective invasion.

The paper investigates how Wnt signaling and tissue deformation coordinate during Hydra regeneration, finding that biomechanical symmetry breaking is regulated by Wnt and stabilized by Hippo-Yap signaling.

This study investigates how tight junctions regulate lumen morphology through hydrostatic pressure and junctional tension in MDCKII cysts.

This study introduces a model to simulate subcellular-level cell proliferation dynamics, including contractile ring formation and division, and shows it replicates tissue-scale multicellular behavior.

This study investigates how curvature gradients and anisotropy drive apicobasal T1 transitions in epithelial tissues through competing mechanical mechanisms.

The paper identifies that spatial inhomogeneity in mechanotransduction via YAP drives compensatory proliferation in response to apoptosis.

This study identifies contact following locomotion as a mechanism driving polar order in collective cell migration through experiments and simulations in Dictyostelium cells.