Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
H. H. Lin, C.-H. Wang, Y.-M. Wu, S.-H. Huang, S. S.-Y. Lin, T. Kato, K. Namba, N. Hosogi, C. Song, K. Murata, C.-H. Yen, T.-L. Hsu, C.-H. Wong, I.-P. Tu, W.-H. Chang
This study uses phase plate cryo-EM to reveal conformational diversity in therapeutic IgG, achieving sub-nanometer resolution of the Fab fragment.
Scientific Reports · Jun 18, 2024Peer-reviewedBiochemistry
P. Sterbova, C.-H. Wang, K. J. D. Carillo, Y.-C. Lou, T. Kato, K. Namba, D.-L. M. Tzou, W.-H. Chang
This study reveals a pH-induced conformational switching mechanism in Betanodavirus protrusions that governs infectivity through dynamic structural changes.
bioRxiv · Mar 8, 2024 · PreprintBiochemistry
M. Mukenhirn, C.-H. Wang, T. Guyomar, M. J. Bovyn, M. F. Staddon, R. Maraspini, L. Lu, C. Martin-Lemaitre, M. Sano, T. Hiraiwa, D. Riveline, A. Honigmann
This study investigates how tight junctions regulate lumen morphology through hydrostatic pressure and junctional tension in MDCKII cysts.
bioRxiv · May 23, 2023 · PreprintCell Biology
J. Foote, T. E. Mattox, A. B. Keeton, X. Chen, F. T. Smith, K. L. Berry, T. W. Holmes, J. Wang, C.-H. Wang, A. B. Ward, A. K. Mitra, V. R. Alcantara, C. Hardy, K. G. Fleten, K. Flatmark, , G. A. Piazza
This paper introduces ADT-007, a novel pan-RAS inhibitor that effectively blocks tumor growth in mouse models of GI cancer by targeting RAS activation and inducing apoptosis.
bioRxiv · May 17, 2023 · PreprintCancer Biology
R. E. Vickman, L. Aaron-Brooks, R. Zhang, N. A. Lanman, B. Lapin, V. Gil, M. Greenberg, T. Sasaki, G. M. Cresswell, M. M. Broman, J. Petkewicz, P. Talaty, B. T. Helfand, A. P. Glaser, C.-H. Wang, , S. W. Hayward
Patient data and mouse models suggest that repurposing tumor necrosis factor alpha blockade reduces inflammation-mediated prostatic hyperplasia.
bioRxiv · Mar 11, 2021Cell Biology
Y.-f. Xu, J. Sun, X. Yu, X. Chen, M. Cui, Z. Yang, C.-h. Liu, X.-z. Yang, Y.-j. Wang, S. Zhang, C. Wang, Z.-y. Zhang, W.-d. Zhao, C.-h. Wang, Z.-l. Ji, , Y.-c. Song
This study identifies how PTP-MEG2 regulates exocytosis by dephosphorylating specific sites on NSF, DYNAMIN2, and MUNC18-1, revealing distinct structural mechanisms for substrate recognition.
bioRxiv · Sep 17, 2020Cell Biology
Y.-C. Tsao, Y.-J. Chang, C.-H. Wang, L. Chen
This study identifies isoplumbagin as a novel NQO1 substrate that exerts anti-cancer effects by modulating mitochondrial function and dynamics in multiple cancer cell lines.
bioRxiv · Apr 28, 2020Pharmacology & Toxicology
S.-L. Chen, C. Z. Zhang, L.-L. Liu, S.-X. Lu, Y.-H. Pan, C.-H. Wang, Y.-F. He, C.-S. Lin, X. Yang, D. Xie, J.-P. Yun
This paper identifies a GYS2/p53 negative feedback loop that suppresses tumor growth in HBV-related hepatocellular carcinoma by regulating glycogen metabolism and p53 activity.
bioRxiv · Jul 20, 2018Pathology
C.-H. Wang, S. Matin, A. B. George, K. S. Korolev
The paper studies how traveling waves in structured environments can become pinned or locked, showing that locked velocities depend on environmental periodicity and are robust to fluctuations.
bioRxiv · Jun 8, 2018Ecology