T. Lemmin

Large transient assemblies of Apaf1 constitute the apoptosome in cells

The paper shows that Apaf1 forms transient foci during apoptosis, which correspond to the apoptosome and regulate apoptosis progression.

The inhibitory mechanism of a small protein reveals its role in antimicrobial peptide sensing

This study reveals how the small protein MgrB inhibits the sensor kinase PhoQ, modulating bacterial virulence and antimicrobial peptide sensing.

Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ

The paper investigates how Mg2+ binding to the sensor domain of PhoQ modulates its kinase activity through allosteric communication between domains.

RosENet: Improving binding affinity prediction by leveraging molecular mechanics energies with a 3D Convolutional Neural Network

RosENet improves binding affinity prediction by combining 3D convolutional neural networks with voxelized molecular mechanics energies, achieving an RMSE of 1.26 on the PDBBind v2016 core set.

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

This study shows that targeting the HIV-1 fusion peptide with specific immunogens induces cross-clade neutralizing antibodies in animals.