Author

T. Lotan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Ecology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 5 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

V. Brekhman· 2 shared A. Augspach· 1 shared A. Malik· 1 shared A. Mandl· 1 shared A. Sboner· 1 shared A.-C. Uldry· 1 shared B. Hanratty· 1 shared D. Aharonovich· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersMicrobiology

V. Brekhman

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Differential response to LSD1 inhibition in prostate cancer reveals a YAP1 vulnerability in the neuroendocrine subtype

S. Jasim, R. Kumar, S. Kim, T. Krueger, I. Coleman, S. Dalrymple, L. Antony, D. Rosen, B. Hanratty, R. Patel, P. Nelson, Z. Aghaei, J. Beumer, M. Haffner, T. Lotan, , W. Brennen

This paper shows that LSD1 inhibition is effective against neuroendocrine prostate cancer (NEPC) and that combining it with YAP/TEAD inhibition enhances treatment efficacy.

bioRxiv · Jan 17, 2024 · PreprintCancer Biology

Selecting 16S rRNA primers for microbiome analysis in a host-microbe system: the case of the jellyfish Rhopilema nomadica

N. Barak, E. Fadeev, V. Brekhman, D. Aharonovich, T. Lotan, D. Sher

This study compares 16S rRNA gene primers for analyzing jellyfish-associated bacterial communities, finding that V3V4 primers outperform others in accuracy and resolution.

bioRxiv · Oct 17, 2022Microbiology

Cellular pathways during spawning induction in the starlet sea anemone Nematostella vectensis

S. Reuven, M. Rinsky, V. Brekhman, A. Malik, O. Levy, T. Lotan

The paper analyzes transcriptional changes during spawning induction in Nematostella vectensis, revealing upregulated signal perception and cytoskeleton processes and downregulated fatty acid metabolism and housekeeping functions.

bioRxiv · Mar 16, 2021Ecology

Role of Specialized mSWI/SNF Complexes in Prostate Cancer Lineage Plasticity

J. Cyrta, A. Augspach, M. R. de Filippo, D. Prandi, P. Thienger, M. Benelli, V. Cooley, R. Bareja, D. Wilkes, S.-S. Chae, P. Cavaliere, N. Dephoure, A.-C. Uldry, S. B. Lagache, S. Cohen, , M. Rubin

The paper investigates the role of mSWI/SNF complexes in NEPC lineage plasticity using patient data and cell models, finding deregulated subunits and SMARCA4 overexpression linked to aggressive disease.

Nature Communications · Nov 3, 2020Peer-reviewedCancer Biology

Transcriptional landscape of PTEN loss in primary prostate cancer

E. L. Imada, D. F. Sanchez, W. Dinalankara, T. Vidotto, E. M. Ebot, S. Tyekucheva, G. R. Franco, L. Mucci, M. Loda, E. M. Schaeffer, T. Lotan, L. Marchionni

The paper identifies a transcriptomic signature of PTEN loss in prostate cancer, revealing immune system activation and cell-cycle gene upregulation, and expands it to include non-coding RNAs.

bioRxiv · Oct 8, 2020 · PreprintCancer Biology