O. Levy

Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants

This study identifies immune programs linked to COVID-19 severity and mortality through longitudinal multi-omics analysis of 1,152 hospitalized patients.

Early cellular and molecular signatures correlate with severity of West Nile Virus infection

The paper identifies cellular and molecular signatures associated with varying severities of West Nile Virus infection using multi-omics analysis of immune responses.

CLOCK evolved in cnidaria to synchronize internal rhythms with diel environmental cues

This study shows that the Clock gene in cnidarians evolved to synchronize circadian rhythms with daily environmental cycles, with partial compensation via light-responsive pathways.

Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance.

Adjuvant Discovery via a High Throughput Screen using Human Primary Mononuclear Cells

This paper describes a high-throughput screening method using human PBMCs to identify adjuvant candidates, resulting in a lead compound with in vivo adjuvanticity.

Shaping neonatal immunization by tuning delivery of synergistic adjuvants via nanocarriers

This study identifies synergistic adjuvants for neonatal immunization using nanocarriers, showing enhanced Th1 bias and humoral responses in mice.

Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses

The paper integrates transcriptional data from 13 vaccines to identify a time-adjusted signature predicting antibody responses across different vaccines.

Determinants of precocious B-cell aging in European adolescences living with perinatally acquired HIV-1 after over 10 years of suppressive therapy

This study identifies factors associated with precocious B-cell aging in adolescents with perinatally acquired HIV on long-term suppressive therapy, linking them to immune dysfunction and reduced vaccine response.

An adjuvanted SARS-CoV-2 RBD nanoparticle elicits neutralizing antibodies and fully protective immunity in aged mice

This study identifies an adjuvanted SARS-CoV-2 RBD nanoparticle that induces neutralizing antibodies and full protection in aged mice.

Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity

This study evaluates AH:CpG adjuvant's ability to enhance RBD vaccine efficacy in aged mice and human elder cells, showing strong neutralizing antibody responses and cytokine production.

Lymphoid follicle formation and human vaccination responses recapitulated in an organ-on-a-chip

This paper demonstrates the formation of lymphoid follicles in a human organ-on-a-chip model and shows improved vaccine responses compared to 2D cultures.

Cellular pathways during spawning induction in the starlet sea anemone Nematostella vectensis

The paper analyzes transcriptional changes during spawning induction in Nematostella vectensis, revealing upregulated signal perception and cytoskeleton processes and downregulated fatty acid metabolism and housekeeping functions.

Proteomics on longitudinal serum samples differentiates localized and disseminated Lyme disease

This study uses serum proteomics to identify biomarkers distinguishing localized and disseminated Lyme disease stages.

Efficient 5-OP-RU-induced enrichment of Mucosal-associated invariant T cells in the murine lung does not enhance control of aerosol Mycobacterium tuberculosis infection.

This study shows that priming MAIT cells in mice with 5-OP-RU and P2C increases their activation and expansion but does not improve control of Mtb infection.

Early birds, late owls, and the ecological role of intra-population chronotype variation

The paper studies intra-population chronotype variation in two Acomys species, finding that circadian clock period length (tau) drives temporal partitioning and suggests adaptive benefits through reduced competition.

Human colon-on-a-chip enables continuous in vitro analysis of colon mucus layer accumulation and physiology

This study develops a human colon-on-a-chip model that replicates the mucus bilayer structure and function, enabling real-time non-invasive analysis of mucus layer dynamics.

Analysis of 19 Heliconiine Butterflies Shows Rapid TE-based Diversification and Multiple SINE Births and Deaths

The paper analyzes TE content in 19 Heliconiine butterfly species, finding rapid diversification, unique SINE lineages, and a correlation between TE bursts and speciation.

The TLR5 agonist flagellin modifies phenotypical and enhances functional activation of lung mucosal antigen presenting cells in neonatal mice

This study shows that flagellin activates neonatal lung APCs more effectively than other PRR agonists, suggesting its potential as an adjuvant for early life mucosal vaccines.

Human bone marrow disorders recapitulated in vitro using organ chip technology

The paper describes a Bone Marrow-on-a-Chip model that mimics bone marrow function and disease states, including drug and radiation responses and Shwachman-Diamond Syndrome abnormalities.

Complex human gut microbiome cultured in anaerobic human intestine chips

This study develops an Organ-on-a-Chip system to culture human intestinal epithelium with gut microbiota, showing increased microbial diversity and barrier function under hypoxia.