Author

P. Nelson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2

Frequent Co-Authors

E. Corey· 2 shared I. Coleman· 2 shared J.-H. Seo· 2 shared M. Brown· 2 shared M. Freedman· 2 shared M. Haffner· 2 shared R. Patel· 2 shared X. Qiu· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

E. Corey

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Author profile →

6 papers

Recent·Most cited

Differential response to LSD1 inhibition in prostate cancer reveals a YAP1 vulnerability in the neuroendocrine subtype

S. Jasim, R. Kumar, S. Kim, T. Krueger, I. Coleman, S. Dalrymple, L. Antony, D. Rosen, B. Hanratty, R. Patel, P. Nelson, Z. Aghaei, J. Beumer, M. Haffner, T. Lotan, , W. Brennen

This paper shows that LSD1 inhibition is effective against neuroendocrine prostate cancer (NEPC) and that combining it with YAP/TEAD inhibition enhances treatment efficacy.

bioRxiv · Jan 17, 2024 · PreprintCancer Biology

Increased chromatin accessibility mediated by nuclear factor I drives transition to androgen receptor splice variant dependence in castration-resistant prostate cancer

L. Poluben, M. Nouri, J. Liang, A. Varkaris, B. Ersoy-Fazlioglu, O. Voznesensky, I. Lee, X. Qiu, L. Cato, J.-H. Seo, M. Freedman, A. Sowalsky, N. Lack, E. Corey, P. Nelson, , S. Balk

This study shows that ARv7 drives AR activity in castration-resistant prostate cancer through increased chromatin accessibility mediated by NFI factors.

bioRxiv · Jan 10, 2024 · PreprintCancer Biology

Differential retention of Pfam domains creates long-term evolutionary trends

J. James, P. Nelson, J. Masel

The paper shows that differential retention of protein domains with specific structural properties drives long-term evolutionary trends in Pfam domains.

bioRxiv · Oct 27, 2022 · PreprintEvolutionary Biology

Harbingers of Aggressive Prostate Cancer: Precision Oncology Case Studies

J. Cyrta, D. Prandi, A. Arora, D. H. Hovelson, A. Sboner, A. Rodriguez, T. Fedrizzi, H. Beltran, D. R. Robinson, A. Gopalan, L. True, P. Nelson, B. D. Robinson, J. M. Mosquera, S. Tomlins, , M. Rubin

This study identifies molecular features of primary prostate cancer and their relation to metastasis using genomic and histopathological analysis.

bioRxiv · Nov 30, 2021 · PreprintCancer Biology

Subtype Heterogeneity and Epigenetic Convergence in Neuroendocrine Prostate Cancer

P. Cejas, Y. Xie, A. Font-Tello, K. Lim, S. Symala, X. Qiu, A. Tewari, N. Shah, H. Nguyen, R. Patel, L. Brown, I. Coleman, W. M. Hackeng, L. Brosens, K. Dreijerink, , H. W. Long

This study identifies two distinct subtypes of neuroendocrine prostate cancer based on neuronal transcription factors and highlights their epigenetic convergence and therapeutic implications.

bioRxiv · Sep 13, 2020Cancer Biology

Modeling the emergence of antibiotic resistance in the environment: an analytical solution for the minimum selection concentration

B. K. Greenfield, S. Shaked, C. F. Marrs, P. Nelson, I. Raxter, C. Xi, T. E. McKone, O. Jolliet

The paper develops a model to predict the minimum selection concentration of antibiotics using MIC and selection coefficient, showing MSC can be much lower than MIC.

bioRxiv · Aug 15, 2017Microbiology