M. Loda

Cis-vaccenic acid is a key product of stearoyl-CoA desaturase 1 and a critical oncogenic factor in prostate cancer

This study identifies cis-vaccenic acid as a critical oncogenic factor in prostate cancer, showing it rescues cell viability loss from SCD1 inhibition and promotes growth.

Canonical AREs are tumor suppressive regulatory elements in the prostate

This study identifies canonical AREs as tumor suppressive regulatory elements in prostate cancer, showing their reactivation can induce death in AR+ cancer cells and is linked to better prognosis.

Integration of Multiple Spatial-Omics Modalities Reveals Unique Insights into Molecular Heterogeneity of Prostate Cancer

This paper integrates multiple spatial-omics modalities in prostate cancer samples to reveal molecular heterogeneity and correlations between lipids and gene expression.

NSD2 maintains lineage plasticity and castration-resistance in neuroendocrine prostate cancer

This study identifies NSD2 as a key driver of lineage plasticity and castration-resistance in neuroendocrine prostate cancer, showing its inhibition can restore sensitivity to AR inhibitors.

Suppression of tumor cell lactate-generating signaling pathways eradicates murine PTEN/p53-deficient aggressive-variant prostate cancer via macrophage phagocytosis

This study shows that blocking lactate-producing pathways in PTEN/p53-deficient prostate cancer enhances macrophage phagocytosis, leading to durable tumor control in mice.

Distinct mesenchymal cell states mediate prostate cancer progression

This study identifies distinct mesenchymal cell states in prostate cancer stroma that correlate with metastatic progression and develops a gene signature to predict patient outcomes.

Using Attention-based Deep Learning to Predict ERG:TMPRSS2 Fusion Status in Prostate Cancer from Whole Slide Images

This paper develops a deep learning model to predict ERG:TMPRSS2 fusion status in prostate cancer from whole slide images and identifies associated morphological features.

Adipose triglyceride lipase is regulated by CAMKK2-AMPK signaling and drives advanced prostate cancer

This study identifies ATGL as a CAMKK2-AMPK target that promotes CRPC progression by enhancing lipase activity and metabolic plasticity, suggesting it as a therapeutic target.

Long Noncoding RNA RROL Provides Chromatin Scaffold for MYC-WDR82 Interaction to Impact Lipid Metabolism and Tumor Cell Growth in Multiple Myeloma

This study identifies RROL as a therapeutically actionable lncRNA in multiple myeloma that supports tumor growth through chromatin scaffolding of MYC-WDR82 interaction.

Compromised CDK12 activity causes dependency on the non-essential spliceosome components

This study shows that compromised CDK12 activity in prostate cancer cells leads to addiction to non-essential spliceosome components and lower DNA methylation, suggesting potential therapeutic targets.

Building tools for machine learning and artificial intelligence in cancer research: best practices and a case study with the PathML toolkit for computational pathology

The paper introduces PathML, a computational pathology toolkit designed for scalability, standardization, and ease of use in cancer research, with applications demonstrated across diverse use-cases.

Extent, impact, and mitigation of batch effects in tumor biomarker studies using tissue microarrays

This study assesses batch effects in TMA-based cancer biomarker studies and shows mitigation methods reduce variance and alter clinical associations.

Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma

The paper investigates the role of pyruvate kinase isoforms in prostate cancer, finding that Pkm1 suppresses cancer while Pkm2 promotes it, and that a PKM1-like activator can suppress tumor progression.

Systemic Tissue and Cellular Disruption from SARS-CoV-2 Infection revealed in COVID-19 Autopsies and Spatial Omics Tissue Maps

This study identifies systemic tissue and cellular disruption from SARS-CoV-2 infection using autopsy and spatial omics data, showing tissue-specific damage and transcriptional changes.

Intra-epithelial non-canonical Activin A signalling safeguards prostate progenitor quiescence

This study identifies non-canonical Activin A signaling as a mechanism maintaining prostate epithelial progenitor quiescence, with implications for cancer and therapy.

Transcriptional landscape of PTEN loss in primary prostate cancer

The paper identifies a transcriptomic signature of PTEN loss in prostate cancer, revealing immune system activation and cell-cycle gene upregulation, and expands it to include non-coding RNAs.

Targeting EZH2 Increases Therapeutic Efficacy of Check-Point Blockade in Models of Prostate Cancer

This study shows that inhibiting EZH2 enhances the effectiveness of PD-1 checkpoint inhibitors in prostate cancer by increasing PD-L1 expression and immune cell infiltration.

Unbiased Assessment of H-STS cells as high-fidelity models for gastro-enteropancreatic neuroendocrine tumor drug mechanism of action analysis

The paper assesses H-STS cells as models for drug mechanism analysis in gastro-enteropancreatic neuroendocrine tumors using molecular criteria rather than histological features.