T. Shima

Augmented-reality-based multi-person exercise has more beneficial effects on mood state and oxytocin secretion than standard solitary exercise

This study compares the effects of standard solitary exercise and AR-based multi-person exercise on mood and oxytocin levels, finding greater mood improvement and oxytocin elevation with the AR condition.

Golgi membrane proteins YIPF3 and YIPF4 regulate turnover of the Golgi apparatus through autophagy

This study identifies YIPF3 and YIPF4 as Golgi-specific autophagy receptors that mediate Golgi turnover via selective autophagy.

Preference of CAMSAP3 for microtubules with expanded lattice contributes to stabilization of the minus end

The paper shows that the D2 region of CAMSAP3 binds to and expands microtubule lattices, stabilizing microtubules and explaining CAMSAP3's unique function.

N-terminal region of Drosophila melanogaster Argonaute2 forms amyloid-like aggregates

This study shows that the N-terminal region of Drosophila melanogaster Argonaute2 forms amyloid-like aggregates, suggesting it functions as a prion-like domain.

Key residue on cytoplasmic dynein for asymmetric unbinding and unidirectional movement along microtubule

This study identifies a key residue in cytoplasmic dynein responsible for asymmetric unbinding and unidirectional movement along microtubules through computational simulations and in vitro experiments.

Accumulation of TERT in Mitochondria Shows Two Opposing Effects on Apoptosis

This study shows that mitochondrial TERT has opposing effects on apoptosis: it initiates cell death early but delays it later, resolving a controversy about its role.

Metabolic flux and flux balance analyses indicate the relevance of metabolic thermogenesis and aerobic glycolysis in cancer cells

The paper uses metabolic flux analysis to show that cancer cells prefer aerobic glycolysis over oxidative phosphorylation due to reduced metabolic heat generation.

A fast and objective hidden Markov modeling for accurate analysis of biophysical data with numerous states

This paper introduces a new HMM algorithm that improves accuracy and objectivity in analyzing biophysical data with many states, achieving faster performance and better handling of complex datasets.

IN VITRO RECONSTITUTION OF DYNEIN FORCE EXERTION IN BULK CYTOPLASM

This study demonstrates that cargo motion in bulk cytoplasm exerts forces on microtubules, revealing how cargo size and MT length influence force efficiency and enabling tug-of-war dynamics.

Implementation of single molecule FRET for visualizing intramolecular movement in CRISPR-Cas9

This paper describes methods to visualize flexible inter-domain movements of Cas9 using single molecule FRET and discusses necessary complementary experiments for accurate analysis.

Diverse stepping motions of cytoplasmic dynein revealed by kinetic modeling

The paper develops a kinetic model of cytoplasmic dynein's bipedal stepping motions, showing how different stepping patterns arise from ATP hydrolysis and conformational changes.

Second harmonic generation polarization microscopy as a tool for protein structure analysis

This paper demonstrates the use of SHG polarization microscopy to detect protein conformational changes in macromolecular assemblies without labeling.

Real-time observation of flexible domain movements in Cas9

This study uses single-molecule FRET to observe dynamic domain movements in Cas9, showing flexibility enables DNA cleavage and sgRNA assembly.