Z. Han

Polydopamine Nanoparticles as Mimicking RPE Melanin for the Protection of Retinal Cells Against Blue Light-Induced Phototoxicity

This study uses polydopamine nanoparticles to mimic RPE melanin and protect retinal cells from blue light-induced phototoxicity in Nrf2-deficient mice.

Collective phases and long-term dynamics in a fish school model with burst-and-coast swimming

This paper introduces a fish school model with burst-and-coast swimming that replicates collective phases like schooling and swarming, but cohesion diminishes over time except in swarming.

Novel Polymycoviruses Are Encapsidated in Filamentous Virions

This paper identifies and characterizes three novel polymycoviruses in phytopathogenic fungi, confirming they are encapsidated in filamentous virions with P-A-S-rich coat proteins.

Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived sSCF

The paper identifies resting NK cells that promote colon cancer liver metastasis by enhancing tumor-derived sSCF through cell-to-cell interactions.

Chromosome segment scanning for gain- or loss-of-function screening (CHASING) and its application in metabolic engineering

The paper introduces CHASING, a method for gain- or loss-of-function screening using chromosome-segment deletions, and applies it to identify metabolic engineering targets in B. subtilis.

De novo multi-mechanism antimicrobial peptide design via multimodal deep learning

This paper introduces M3-CAD, a deep learning pipeline for designing multi-mechanism antimicrobial peptides to combat multidrug-resistant organisms, showing effectiveness in a skin wound infection model.

UDP-glucosyltransferase 71C4 regulates seed development by redistributing phenylpropanoid metabolism in cotton

This study identifies UGT71C4's role in regulating seed development and yield traits in cotton by modulating phenylpropanoid metabolism, lignin, and flavonoid pathways.

Dissecting Mechanisms of Ligand Binding and Conformational Changes in the Glutamine-Binding Protein

This study investigates the ligand binding mechanism of GlnBP in E. coli, finding that conformational changes and ligand binding are correlated, and that the induced-fit mechanism is more consistent with the data than conformational selection.

Rho of plant GTPase MxROP1 regulates Fe deficiency responses by targeting Zinc Ribbon 3 in apple rootstock

This study identifies MxROP1 as a regulator of Fe deficiency responses in apple rootstock by interacting with ZR3.1 and modulating its stability and interaction with MxbHLH39.

Glyceroglycolipids are essential for Burkholderia cenocepacia intracellular survival by preventing phagolysosome acidification

A potent MAPK13-14 inhibitor prevents airway inflammation and mucus production

This paper develops a potent MAPK13-14 inhibitor, NuP-3, which reduces airway inflammation and mucus production in human airway models and minipig disease models.

Tuning social interactions' strength drives collective response to light intensity in schooling fish

This study shows that varying light intensity affects social interactions and collective behavior in schooling fish by altering their responses to obstacles and group motion patterns.

Microbiota Succession Influences Nematode Physiology in a Beetle Microcosm Ecosystem

This study shows nematodes influence microbial succession in beetle grub decay by selecting high-nutrition microbes, which in turn affects nematode metabolism and dauer larva formation.

Multi-omics of the gut microbial ecosystem in the immunotherapy resistance in microsatellite instability-high gastrointestinal cancer patients

The paper uses multi-omics data to identify gut microbiome and metabolite markers of immunotherapy resistance in MSI-H/dMMR gastrointestinal cancer patients and develops a predictive model with 0.83 accuracy.

Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance

The paper identifies KDM2A as a selective vulnerability in ALT-dependent cancers by showing its role in telomere cluster dissolution through SENP6-mediated SUMO deconjugation.

Enhancing detectable fluorescence fluctuation for high-throughput and four-dimensional live-cell super-resolution imaging

This paper introduces SACD, a super-resolution imaging method that reduces acquisition time and improves resolution, enabling high-throughput and 4D live-cell imaging.

Genetically engineered mesenchymal stem cells as a nitric oxide reservoir for acute kidney injury therapy

This paper genetically engineers mesenchymal stem cells to act as a nitric oxide reservoir, enhancing therapeutic efficiency in acute kidney injury by precise spatiotemporal NO release.

Development of an affinity-enhanced clinical candidate TCR targeting NY-ESO-1 with optimal potency and high specificity

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

A special satellite-like dsRNA of a novel hypovirus from Pestalotiopsis fici broadens the definition of satellite

The paper identifies and characterizes a novel hypovirus and its satellite-like dsRNA from Pestalotiopsis fici, showing it lacks a poly(A) tail and ORF, and negatively regulates the helper virus.

TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity

The paper shows TIR domains catalyze ADP-ribosylation reactions to produce signaling molecules that specifically activate the EDS1-SAG101-NRG1 immunity branch in plants.

Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity

The paper identifies TIR-catalyzed pRib-AMP/ADP as a signaling molecule in plant immunity and shows it binds to the EDS1-PAD4 complex.

A wheat resistosome defines common principles of immune receptor channels

This study reports the cryo-EM structure of the wheat CNL Sr35 resistosome and shows its structural and functional conservation with the Arabidopsis ZAR1 resistosome.

TIR domains of plant immune receptors are 2',3'-cAMP/cGMP synthetases mediating cell death

Efficient transformation and genome editing of watermelon assisted by genes that encode developmental regulators

This study improves watermelon transformation efficiency using AtGRF5 and Agrobacterium GV3101, achieving 25% efficiency and enabling CRISPR/Cas9-based knockout mutants.

Wound-like tumor periphery in human breast cancer predicts a convergent drug nonresponse

The paper identifies a wound-like tumor periphery in breast cancer as a uniparameter marker predicting multidrug nonresponse and poor prognosis across molecular subtypes.

The impact of individual perceptual and cognitive factors on collective states in a data-driven fish school model

This paper uses a data-driven fish school model to study how perceptual and cognitive factors affect collective swimming patterns in Hemigrammus rhodostomus, finding that minimal alignment and attraction are required for schooling, and that stronger interactions or larger group sizes can disrupt coordination.

Pharmacokinetics and biodistribution of extracellular vesicles administered intravenously and intranasally to Macaca nemestrina

This study investigates the pharmacokinetics and biodistribution of extracellular vesicles in macaques via intravenous and intranasal routes, finding longer plasma circulation times and organ uptake with IV administration, but limited systemic distribution with IN.

Co3O4 /PAn Magnetic Nanoparticle-Modified Electrochemical Immunosensor for Azocyclotin

The paper develops an electrochemical immunosensor for detecting azocyclotin residues using Co3O4/PAn nanoparticles, achieving good sensitivity and accuracy in agricultural samples.

Immune elicitation by sensing the conserved signature from phytocytokines and microbes via the Arabidopsis MIK2 receptor

The paper identifies MIK2 as a plant receptor that recognizes conserved peptide motifs from phytocytokines and microbial proteins, triggering immune responses through a signaling relay.

Compound FC-10696 Inhibits Egress and Spread of Marburg Virus

The paper identifies FC-10696 as a novel compound that inhibits Marburg virus egress and spread, showing antiviral effects in cell cultures and animal models.