Histone H3 Orchestrates the Ubiquitination of Nucleosomal H2A by BRCA1/BARD1-UbcH5c Complex
A. R. Goldman, T. Shah, H. Torabifard
This study uses molecular dynamics simulations to investigate how the BRCA1/BARD1-UbcH5c complex ubiquitinates H2A, highlighting the role of H3 in orienting the E2-Ub complex.
bioRxiv · Apr 9, 2024 · PreprintBiochemistry