T. W. Muir

This study uses a protein trans-splicing technology to reveal distinct phases of signaling in cancer-related proteins like BCR/ABL and DNAJB1/PRKACA.

This paper introduces a photo-proximity labeling system using visible light to capture protein interactomes with high temporal resolution and correlates it with imaging and proteomics.

This study identifies MroQ as the second protease in the S. aureus agr quorum sensing pathway, showing its role in AIP biosynthesis and revealing molecular features guiding its cleavage activity.

This paper introduces Chroma-Map, a method to track chromatin state changes by using photo-proximity labeling to analyze protein interactions in the nucleus, showing its application in studying cancer mutations and drug effects.

This study investigates how PRC2 interacts with chromatin using single-molecule force spectroscopy and simulations, revealing new binding configurations and their regulation.

This study identifies EZHIP as a PRC2 inhibitor in PFA ependymomas that mimics the H3 K27M oncohistone by disrupting PRC2 activity and H3K27me3 levels.