Author

S. High

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:proteomics· 6 Organism:human· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

S. O'Keefe· 3 shared P. Roboti· 2 shared W. Q. Shi· 2 shared Y. Lu· 2 shared A. D. Davidson· 1 shared A. E. Firth· 1 shared A. Hoyle· 1 shared A. PICKARD· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersMicrobiology

S. O'Keefe

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity

H. Stewart, Y. Lu, S. O'Keefe, A. Valpadashi, L. D. Cruz-Zaragoza, H. A. Michel, S. K. Nguyen, G. W. Carnell, N. Lukhovitskaya, R. Milligan, I. Jungreis, V. Lulla, A. D. Davidson, D. A. Matthews, S. High, , A. E. Firth

This study identifies ORF3c as a SARS-CoV-2 protein that localizes to mitochondria and inhibits IFN-β production without affecting NF-κB or JAK-STAT signaling.

bioRxiv · Nov 15, 2022Microbiology

Proteomics identifies substrates and a novel component in hSnd2-dependent ER protein targeting

A. Tirincsi, S. O Keefe, D. Nguyen, M. Sicking, J. Dudek, F. Foerster, M. Jung, D. Hadzibeganovic, V. Helms, S. High, R. Zimmermann, S. Lang

The paper identifies substrates and a novel component, hSnd3, in the hSnd2-dependent ER protein targeting pathway through proteomic analysis.

bioRxiv · Apr 27, 2022Cell Biology

Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex

P. Roboti, C. Lawless, S. High

The paper identifies MAVS as a client of the BAG6 complex, showing its role in quality control and innate immune response modulation.

bioRxiv · Dec 2, 2021Biochemistry

Co-translational biogenesis of lipid droplet integral membrane proteins

P. Leznicki, W. Q. Shi, S. High

The paper shows that lipid droplet membrane proteins are inserted into the ER co-translationally via the EMC, with topology reorientation leading to hairpin loop formation.

bioRxiv · Aug 5, 2021Biochemistry

Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis

J. CHANG, A. PICKARD, J. A. Herrera, S. O'Keefe, M. Hartshorn, R. GARVA, A. Hoyle, L. Dingle, C. Zeltz, J. Wong, A. Reid, R. V. Venkateswaran, Y. Lu, P. Caswell, S. High, , K. E. KADLER

This study shows that circadian-regulated endocytic recycling is essential for collagen fibril assembly and is disrupted in fibrosis.

bioRxiv · Mar 25, 2021Cell Biology

Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor

S. O'Keefe, P. Roboti, K. B. Duah, G. Zong, H. Schneider, W. Q. Shi, S. High

This study shows that ipomoeassin F inhibits the ER membrane translocation of SARS-CoV-2 spike, ORF8, and ACE2 proteins in vitro.

bioRxiv · Nov 24, 2020Biochemistry