Human endogenous retrovirus activation contributes to biliary atresia pathogenesis through re-education of resident macrophages
J. Sheng, J. Zhang, Y. Zhao, J. Song, J. Tang, X. Wang, Y. Ji, J. Wu, T. Li, H. Zhang, V. Tano, S. R. Langley, X. Bai, T. Liang
This study identifies HERV activation in BA livers and shows it re-educates macrophages, impairing neutrophil recruitment and causing liver damage, suggesting therapeutic targets.
bioRxiv · Mar 11, 2022 · PreprintPathology