W. J. Chng

This study shows that aberrant non-canonical NF-kappaB signalling reprograms the epigenome to drive oncogenic transcriptomes in multiple myeloma by promoting super-enhancers and cis-regulatory interactions.

This study identifies ADAR2 downregulation in t(8;21) AML and shows its role in suppressing leukemogenesis through RNA editing.

This study shows TRIP12 suppresses EMT and metastasis by inhibiting ZEB1/2 in breast cancer, based on patient data and cell experiments.

This study identifies calcitriol, the active form of vitamin D, as a potent inhibitor of SARS-CoV-2, suggesting its potential as a prophylactic agent against COVID-19.

This study maps 3D genome organization in normal and AML haematopoietic stem cells, finding increased chromatin loops to oncogenes in AML and identifying MEIS1 and HOXA9 as key oncogenes regulated by these interactions.

This study shows that combining a BET PROTAC (ARV 825) with a CDK9 inhibitor (AZD 4573) effectively reduces multiple myeloma cell viability and induces apoptosis.