S. Jha

Impairment of proteasome-associated deubiquitinating enzyme Uchl5/UBH-4 affects autophagy

This study shows that reducing Uchl5/UBH-4 impairs autophagy in human cells and varies by tissue in C. elegans.

Oryza genera-specific novel Histone H4 variant predisposes H4 Lysine5 Acetylation marks to modulate salt stress responses

The paper identifies a novel histone H4 variant in Oryza that modulates salt stress responses through chromatin remodeling and acetylation marks.

The alphavirus TF protein plays a critical role in promoting viral propagation by altering cell-cell boundaries

This paper identifies the alphavirus TF protein's role in promoting viral propagation by altering cell-cell boundaries through downregulation of Scribble.

Detergent induced structural perturbations in peanut agglutinin: Insights from spectroscopic and molecular dynamic simulation studies

This study investigates how SDS and CTAB detergents affect the structure of peanut agglutinin using spectroscopic and molecular dynamics simulations, revealing structural perturbations and conformational changes.

Mutations in S2 subunit of SARS-CoV-2 Omicron spike strongly influence its conformation, fusogenicity and neutralization sensitivity

This study investigates how mutations in the S2 subunit of SARS-CoV-2 Omicron spike affect its structure, fusogenicity, and neutralization sensitivity.

E4F1 and ZNF148 are transcriptional activators of the A57C and wildtype TERT promoter

The paper identifies E4F1 and ZNF148 as transcriptional activators of the A57C and wildtype TERT promoter, respectively, and shows their role in upregulating TERT transcription and telomerase activity.

Adaptive Ensemble Refinement of Protein Structures in High Resolution Electron Microscopy Density Maps with Radical Augmented Molecular Dynamics Flexible Fitting

This paper introduces an adaptive ensemble refinement method for protein structures using MDFF and RADICAL-Cybertools, improving correlation with cryo-EM density maps by 40%.

In vitro reconstitution demonstrates the amyloid-beta mediated myelin membrane deformation

This study shows A{beta}-40 induces myelin membrane tubulation in vitro through binding and aggregation, revealing mechanisms of potential neuronal demyelination in Alzheimer's Disease.

Integrative Epigenomic and High-Throughput Functional Enhancer Profiling Reveals Determinants of Enhancer Heterogeneity in Gastric Cancer

The paper identifies enhancer heterogeneity in gastric cancer by integrating epigenomic data and functional assays, linking it to genetic and regulatory factors.

High Throughput Virtual Screening and Validation of a SARS-CoV-2 Main Protease Non-Covalent Inhibitor

This paper identifies a novel non-covalent inhibitor of SARS-CoV-2 main protease through high throughput virtual screening, validated by biochemical assays, X-ray crystallography, and molecular dynamics simulations.

Immunogenicity and protective efficacy of a highly thermotolerant, trimeric SARS-CoV-2 receptor binding domain derivative

This study designs a thermotolerant trimeric RBD vaccine candidate that elicits strong neutralizing antibodies against multiple SARS-CoV-2 variants in animal models.

AI-Driven Multiscale Simulations Illuminate Mechanisms of SARS-CoV-2 Spike Dynamics

This paper develops an AI-driven workflow to simulate SARS-CoV-2 spike protein dynamics, revealing glycan shield structure, spike glycans' role in infectivity, and spike-ACE2 interactions.

The oncogenic E3 ligase TRIP12 suppresses epithelial-mesenchymal transition (EMT) and metastasis-related processes through ZEB1/2

This study shows TRIP12 suppresses EMT and metastasis by inhibiting ZEB1/2 in breast cancer, based on patient data and cell experiments.

Boosting with ALVAC-HIV and AIDSVAX B/E enhances Env constant region 1 and 2 antibody-dependent cellular cytotoxicity

The paper shows that boosting RV144 vaccine recipients with ALVAC-HIV and AIDSVAX B/E increases C1C2-specific antibody-dependent cellular cytotoxicity breadth and potency.